| Identification | More | [Name]
Methylene-bis(4-cyclohexylisocyanate) | [CAS]
5124-30-1 | [Synonyms]
4,4'-DIISOCYANATO-METHYLENEDICYCLOHEXANE
4,4'-HMDI
4,4'-METHYLENEBIS(CYCLOHEXYL ISOCYANATE)
BIS(4-ISOCYANATOCYCLOHEXYL)METHANE
DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE
HMDI
HYDROGENATED MDI
1,1’-methylenebis(4-isocyanato-cyclohexan
1,1’-methylenebis[4-isocyanato-cyclohexan
4,4'-Methylenedi(cyclohexyl isocyanate)
cp99173
cyclohexane,1,1’-methylenebis[4-isocyanato-
dmdi
hylenew
Isocyanic acid, methylenedi-4,1-cyclohexylene ester
Isocyanicacid,methylene-di-4,1-cyclohexyleneester
isocyanicacid,methylenedi-4,1-cyclohexyleneester
picm
reducedmdi
rmdi | [EINECS(EC#)]
225-863-2 | [Molecular Formula]
C15H22N2O2 | [MDL Number]
MFCD00015405 | [Molecular Weight]
262.35 | [MOL File]
5124-30-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Liquid.Soluble in acetone;reacts with water or ethanol. | [Melting point ]
25°C | [Boiling point ]
168 °C / 1.5mmHg | [density ]
1.066 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.001Pa at 20℃ | [refractive index ]
n20/D 1.497(lit.)
| [Fp ]
>230 °F
| [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless | [Water Solubility ]
Insoluble/Reactive | [BRN ]
2217800 | [Exposure limits]
TLV-TWA 0.0535 mg/m3 (0.005 ppm)
(ACGIH). | [Stability:]
Hygroscopic | [Major Application]
environmental | [InChI]
1S/C15H22N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h12-15H,1-9H2 | [InChIKey]
KORSJDCBLAPZEQ-UHFFFAOYSA-N | [SMILES]
O=C=NC1CCC(CC1)CC2CCC(CC2)N=C=O | [LogP]
6.11 at 20℃ | [CAS DataBase Reference]
5124-30-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Cyclohexane, 1,1'-methylenebis[4-isocyanato-(5124-30-1) | [EPA Substance Registry System]
5124-30-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H315-H317-H319-H331-H334-H335 | [Precautionary statements ]
P261-P264-P280-P302+P352-P304+P340+P311-P305+P351+P338 | [Hazard Codes ]
T | [Risk Statements ]
R23:Toxic by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S1/2:Keep locked up and out of the reach of children . | [OEL]
Ceiling: 0.01 ppm (0.11 mg/m3) | [RIDADR ]
UN 2206 6.1/PG 2
| [WGK Germany ]
1
| [RTECS ]
NQ9250000
| [TSCA ]
Yes | [HS Code ]
2929.10.8090 | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 | [Safety Profile]
Poison by inhalation.
Mildly toxic by ingestion. When heated to
decomposition it emits very toxic fumes of
NOx and CN-. | [Hazardous Substances Data]
5124-30-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
Clear colorless to light-yellow liquid. | [Reactivity Profile]
Isocyanates and thioisocyanates, such as 1,1-METHYLENE BIS(4-ISOCYANATOCYCLOHEXANE)(5124-30-1), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)]. | [Air & Water Reactions]
Reacts with water to form CO2 | [Hazard]
Strong skin and eye irritant. Respiratorysensitization and lower respiratory tract irritant. | [Potential Exposure]
A potential danger to those involved
in the manufacture of this compound or its use in the production of light-stable, nonyellowing polyurethane resins.
| [Fire Hazard]
Flash point data for this chemical are not available. 1,1-METHYLENE BIS(4-ISOCYANATOCYCLOHEXANE) is probably combustible. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy.
| [Shipping]
UN2206 Isocyanates, toxic, n.o.s. or Isocyanate
solutions, toxic, n.o.s., flash point .61C and boiling point
,300C, Hazard Class: 6.1; Labels: 6.1-Poisonous materials., Technical Name Required. | [Incompatibilities]
May form explosive mixture with air.
Isocyanates are highly flammable and reactive with many
compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause
fires or explosions. Reaction with moist air, water or alcohols
may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases,
including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of
fumes in the air. Incompatible with amines, aldehydes, alkali
metals, ammonia, carboxylic acids, caprolactum, alkaline
materials, glycols, ketones, mercaptans, hydrides, organotin
catalysts, phenols, strong acids, strong bases, strong reducing
agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Attacks some
plastics, rubber and coatings. Contact with metals may evolve
flammable hydrogen gas. May accumulate static electrical
charges, and may cause ignition of its vapors. May slowly
polymerize if heated above 122F/50C. Contact with metals
may evolve flammable hydrogen gas. | [Description]
Methylene bis (4-cyclohexylisocyanate) (HMDI) (CAS No.
5124-30-1) is a clear to pale yellow liquid, which is soluble in
acetone water and is incompatible with alcohols, amines,
bases, acids, and may slowly polymerize if heated above 50 ℃.
HMDI reacts with water and alcohol. | [Chemical Properties]
DMDI is a clear, colorless to light-yellow
liquid. | [Chemical Properties]
Liquid.Soluble in acetone;reacts with water or ethanol. | [Uses]
HMDI has excellent light stability and the stability of the six membered ring structure, has excellent weather resistance and excellent mechanical properties of polyurethane material, and is especially suitable for the production of high performance elastic body, a water polyurethane resin and UV resin. | [Uses]
In the manufacture of polymers | [Uses]
Methylene bis(4-cyclohexylisocyanate) isused to produce urethane foam with colorstability. | [Definition]
ChEBI: A diisocyanate consisting of dicyclohexylmethane with two isocyanate groups at the 4- and 4'-positions. | [Health Hazard]
Studies on test animals indicate that methy-lene bis(4-cyclohexylisocyanate) is highlytoxic by an inhalation route and can causesevere skin reaction. Exposure to 20 ppmfor 5 hours produced irritation of the respiratory tract, tremor, convulsion, congestion oflungs, and edema in rats. The symptoms atlower levels were decreased as to respirationrate and pulmonary irritation.
Contact with the skin can produce severeirritation, erythema, and edema. The oraltoxicity of this compound is very low.
LD50 value, oral (rats): 9900 mg/kg
There is no report of the compound’smutagenicity or carcinogenicity. | [Flammability and Explosibility]
Nonflammable | [Synthesis]
To a clean 25 mL reaction tube was added 0.0407 g (0.02 mmol) of nickel-centered modified unilaterally with Tris derivatives
The polymetallic oxoate [[N(C4H9)4]4[NiMo6O18(OH)3{(OCH2)3CCH2OH}]-13H2O centered on nickel
(CH2OH-NiMo6), 6 mL of the solvent t | [Environmental Fate]
HMDI is a synthetic organic chemical which does not occur
naturally in the environment. At room temperature, it is
a liquid. HMDI hydrolyzes rapidly in water, producing
methylene bis(4-cyclohexylamine). The half-life for HMDI is
approximately 2 h. Due to its rapid hydrolysis, transport
between environmental compartments is unlikely to occur.
Because of the rapid hydrolysis, the assessment of the
substance is based on the hydrolysis product
methylenebis(cyclohexylamine) and not on HMDI. The
hydrolysis product was not classified as a PBT (persistent,
bioaccumulative, toxic) substance. These data indicate that
HMDI is not readily biodegradable. However, due to its rapid
hydrolysis, HMDI is neither persistent in the water compartment
nor bioaccumulative. The calculated Koc-value indicates
that HMDI may strongly adsorb to soil; however, any emission
to the terrestrial compartment would be affected by
humidity and, therefore, terrestrial accumulation is not expected
to occur. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Methylene bis(4-cyclohexylisocyanate) must bestored to avoid contact with alcohols, since violent reactionsoccur. Store in tightly closed containers in a cool,well-ventilated area away from moisture, heat, air, amines,strong bases, and chemically active metals. | [Toxicity evaluation]
The toxicological properties of isocyanates are attributed to
the –N=C=O group. Skin sensitization with HMDI is
thought to be associated with the activation and proliferation
of lymphocytes in lymph nodes draining the site of
exposure. Analysis of the nature and kinetics of the cytokine
production (which regulates lymphocyte production) postexposure
to HMDI revealed that both interleukin-1 (IL-1)
and IL-6 were induced in a biphasic manner. The ordered
and transient pattern of cytokine production that occurs
during the afferent phase of contact sensitization suggests
that sequential cytokine signals may be involved in regulating
the characteristics of the response generated within
the draining lymph node. | [Waste Disposal]
Methylene bis(4-cyclohexylisocyanate) isdissolved in acetone or any other combustible solvent and burned in a chemicalincinerator equipped with an afterburner andscrubber. |
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J & K SCIENTIFIC LTD.
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