| Identification | Back Directory | [Name]
Bromo-PEG2-azide | [CAS]
530151-56-5 | [Synonyms]
Br-PEG2-N3
530151-56-5
Azido-PEG2-Br
Bromo-PEG2-azide
N3-PEG2-CH2CH2Br
Azido-PEG3-bromide
Bromo-PEG2-C2-azide
1-(2-Azidoethoxy)-2-(2-bromoethoxy)ethane | [Molecular Formula]
C6H12BrN3O2 | [MDL Number]
MFCD25424115 | [MOL File]
530151-56-5.mol | [Molecular Weight]
238.082 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG2-azide is a heterobifunctional crosslinking reagent.. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The bromide (Br) is a good leaving group for nucleophilic substitution. | [Biological Activity]
Bromo-PEG2-C2-azide is a non-degradable ADC linker for the synthesis of antibody drug conjugates (ADCs),it is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Non-cleavable < span> | PEGs | |
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T&W GROUP
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Nextpeptide Inc
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