| Identification | Back Directory | [Name]
4-Hydroxymethylbenzocyclobutene | [CAS]
53076-11-2 | [Synonyms]
4-HYDROXYBENZOCYCLOBUTENE
4-hydroxymethylbenzocyclobutene
Bicyclo[4.2.0]octa-1,3,5-triene-3-methanol
Bicyclo[4.2.0]octa-1,3,5-trien-3-ylmethanol
4-bicyclo[4.2.0]octa-1(6),2,4-trienylmethanol
Bicyclo[4.2.0]octa-1,3,5,7-tetraen-3-ylMethanol
4-bicyclo[4.2.0]octa-1(6),2,4,7-tetraenylmethano
4-bicyclo[4.2.0]octa-1(6),2,4,7-tetraenylmethanol
4-Hydroxymethylbenzocyclobutene ISO 9001：2015 REACH
4-HMBCB 4-hydroxymethylbenzocyclobutene | [Molecular Formula]
C9H10O | [MDL Number]
MFCD09752661 | [MOL File]
53076-11-2.mol | [Molecular Weight]
134.18 |
| Chemical Properties | Back Directory | [Boiling point ]
266.3±9.0 °C(Predicted) | [density ]
1.170±0.06 g/cm3(Predicted) | [refractive index ]
1.62 | [Fp ]
130.67ºC | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.50±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [InChI]
InChI=1S/C9H10O/c10-6-7-1-2-8-3-4-9(8)5-7/h1-2,5,10H,3-4,6H2 | [InChIKey]
JJVAJBCHJBHRNT-UHFFFAOYSA-N | [SMILES]
C12C(CC1)=CC=C(CO)C=2 | [LogP]
1.66270 |
| Hazard Information | Back Directory | [Uses]
4-Hydroxymethylbenzocyclobutene is a colorless liquid and can be used as an organic intermediate.
| [Preparation]
The preparation of 4-hydroxymethylbenzocyclobutene: To a stirred solution of 1.32 g of 4-formylbenzocyclobutene in 15 mL of ethanol at room temperature is added 0.38 g of sodium borohydride. The reaction mixture is stirred for 2 h at room temperature. Ethanol is removed using a rotary evaporator and the residual material is diluted with 50 mL of water.
The aqueous mixture is extracted with ethyl acetate. The ethyl acetate layer is washed with water and with saturated sodium chloride brine and dried over anhydrous magesium sulfate. The solution is filtered and solvent is removed from the filtrate. The yield of 4-hydroxymethylbenzocyclobutene is 1.27 g (95%, m.p. 70° C. from hexanes). |
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