| Identification | More | [Name]
Tetraethyl ammonium chloride | [CAS]
56-34-8 | [Synonyms]
ETAMON CHLORIDE
TEA
TEA CHLORIDE
TETRAETHYLAMMONIUM CHLORIDE
Ethanaminium,N,N,N-triethyl-,chloride
n,n,n-triethyl-ethanaminiuchloride
n,n,n-triethylethanaminiumchloride
teac
tetraethyl-ammoniuchloride
Tetraethylammonium choride
TETRAETHYLAMMONIUM CHLORIDE SOLUTION
TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL AR BIOLOGY
TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL GRADE
TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG
Tetraethylammonium
TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT
AMMONIUM,TETRAETHYL-,CHLORIDE
TETRAETHYLAMINEHYDROCHLORIDE
Tetraethylammonium chloride monohydrate, 99+%
Tetraethylammonium chloride ,98% | [EINECS(EC#)]
200-267-5 | [Molecular Formula]
C8H20ClN | [MDL Number]
MFCD00011828 | [Molecular Weight]
165.7 | [MOL File]
56-34-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
39°C | [Boiling point ]
273.32°C (rough estimate) | [density ]
1.08 | [refractive index ]
1.5480 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
methanol: 0.1 g/mL, clear, colorless
| [form ]
Crystalline Powder | [color ]
white to light yellow
| [PH]
4.0 to 7.0(50g/L, 25℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. Protect from moisture. | [Water Solubility ]
Soluble in water, ethanol, chloroform, or acetone
| [Sensitive ]
Hygroscopic | [λmax]
λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03 | [Detection Methods]
T,NMR | [Merck ]
9200 | [BRN ]
3563247 | [InChIKey]
YMBCJWGVCUEGHA-UHFFFAOYSA-M | [Uses]
Medicine (nerve-blocking agent). | [CAS DataBase Reference]
56-34-8(CAS DataBase Reference) | [EPA Substance Registry System]
56-34-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
BS6125000
| [F ]
3-10 | [TSCA ]
Yes | [HS Code ]
29239000 | [Toxicity]
LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Definition]
ChEBI: A quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. | [General Description]
| [Biological Activity]
Non-selective K + channel blocker. | [Biochem/physiol Actions]
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax). | [in vitro]
tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1]. | [in vivo]
vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2] | [storage]
Room temperature (desiccate) | [Purification Methods]
Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.] | [References]
[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6. |
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