| Identification | More | [Name]
4-(Aminomethyl)benzoic acid | [CAS]
56-91-7 | [Synonyms]
4-(AMINOMETHYL)BENZOIC ACID
4-CARBOXYBENZYLAMINE
AMINOMETHYL BENZOIC ACID
H-4-AMB-OH
H-(4)AMBZ-OH
LABOTEST-BB LT00053184
NH2-CH2-PH(4)-COOH
PAMBA
P-(AMINOMETHYL)BENZOIC ACID
RARECHEM AL BW 0005
TIMTEC-BB SBB006704
-Amino-p-toluicacid
Aminomethylbenzoic acid CP2000
Benzoic acid, 4-(aminomethyl)-(9CI)
4-CARBOXYLBENZYLAMINE
p-Aminomethylbenzoic
à-amino-p-toluic acid
4-(AMINOMETHYL)BENZOIC ACIDTRANEXAMIC ACID
4-Aminomethylbenzonium acid
Gumbix | [EINECS(EC#)]
200-297-9 | [Molecular Formula]
C8H9NO2 | [MDL Number]
MFCD00010203 | [Molecular Weight]
151.16 | [MOL File]
56-91-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
≥300 °C (lit.) | [Boiling point ]
273.17°C (rough estimate) | [density ]
1.2023 (rough estimate) | [refractive index ]
1.5810 (estimate) | [storage temp. ]
Store at 0-5°C | [solubility ]
Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated) | [form ]
Powder | [pka]
3.75±0.10(Predicted) | [color ]
White to almost white | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Slightly soluble in water. Insoluble in ethanol, benzene and chloroform. | [BRN ]
1100606 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11) | [InChIKey]
QCTBMLYLENLHLA-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=C(CN)C=C1 | [CAS DataBase Reference]
56-91-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29224900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Questions And Answer | Back Directory | [Description]
4-(Aminomethyl)benzoic acid is a organic compound that can serve as a type 2 antifibrinolytic agent used in the treatment of fibrotic skin disorders, such as Peyronie's disease. It is believed that 4-(Aminomethyl)benzoic acid is effective to increase the oxygen uptake at the tissue level and enhance activity of monoamine oxidase, thus to promote the degradation of serotonin, which in excess, may lead to fibrotic changes. It is also administrated by mouth to treat several skin conditions including vitiligo, pemphigus, dermatomyositis, morphea, lymphoblastoma cutis and scleroderma. It is sometimes used in pill form by patients suffering from irritable bowel syndrome to treat the relevant gastrointestinal symptoms and applied in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels. Besides, it can also serve as nutritional supplements to darken gray hair, prevent hair loss, make skin look younger and prevent sunburn and its benefits are claimed for people with fatigue, irritability, depression, weeping eczema, scleroderma, patchy pigment loss in skin, and premature grey hair.
| [References]
https://en.wikipedia.org/wiki/4-Aminobenzoic_acid
https://www.alfa.com/en/catalog/B23519/
https://pubchem.ncbi.nlm.nih.gov/compound/4-aminobenzoic_acid#section=Top
http://www.webmd.com/vitamins-supplements/ingredientmono-1004-PABA+PARA-AMINOBENZOIC+ACID+PABA.aspxactiveIngredientId=1004&activeIngredientName=PABA
|
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
4-(Aminomethyl)benzoic Acid is a type 2 antifibrinolytic agent. | [Definition]
ChEBI: Aminomethylbenzoic acid is a member of benzoic acids. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
General procedure for the synthesis of 4-(aminomethyl)benzoic acid from 4-cyanobenzoic acid: 4-cyanobenzoic acid (500 g, 3.4 mol) was suspended in methanol (5 L) with Raney nickel catalyst (100 g) and subjected to catalytic hydrogenation under hydrogen pressure of 10 kg/cm2 for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration followed by distillation under reduced pressure to remove the solvent methanol, resulting in the white solid product 4-(aminomethyl)benzoic acid (430 g, 84% yield). |
|
| Company Name: |
yxinchem Gold
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| Telephone: |
+86-0710-4323688 +86-18071785587 |
| Website: |
http://www.yxinchem.com |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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