| Identification | More | [Name]
Methyl-DL-serine hydrochloride | [CAS]
5619-04-5 | [Synonyms]
DL-SERINE METHYL ESTER HYDROCHLORIDE
DL-SERINE-OME HCL
H-DL-SER-OME HCL
METHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE
TIMTEC-BB SBB004026
DL-SERINE METHYL ESTER HYDROCHLORIDE CRYSTALLINE
Serine, methyl ester, hydrochloride
Methyl-DL-serine hydrochloride
DL-Serine methyl ester hydrochloride, 98+%
(±)-Serine methyl hydrochloride
DL-Serine methyl hydrochloride
rac-(R*)-2-Amino-3-hydroxypropanoic acid methyl·hydrochloride | [EINECS(EC#)]
227-047-1 | [Molecular Formula]
C4H10ClNO3 | [MDL Number]
MFCD00012593 | [Molecular Weight]
155.58 | [MOL File]
5619-04-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
134-136 °C(lit.)
| [density ]
1.37g/cm3 at 20℃ | [storage temp. ]
−20°C
| [solubility ]
Methanol, Water | [form ]
Solid | [color ]
White to Off-White | [Sensitive ]
Moisture Sensitive | [BRN ]
6067970 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C4H9NO3.ClH/c1-8-4(7)3(5)2-6;/h3,6H,2,5H2,1H3;1H | [InChIKey]
NDBQJIBNNUJNHA-UHFFFAOYSA-N | [SMILES]
C(N)(CO)C(=O)OC.Cl | [LogP]
-2 at 20℃ and pH7 | [Surface tension]
76mN/m at 1g/L and 20℃ | [CAS DataBase Reference]
5619-04-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29225090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
D,L-Serine Methyl Ester Hydrochloride is used as a reactant in the preparation of chicoric acid analogs as HIV-1 integrase inhibitors. Also used in the total synthesis of (-)-Hennoxazole A. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
100 mL of methanol was added to a 30 mL triple-necked vial placed on a mechanical stirrer and cooled in an ice-water bath. 6.6 ml of dichlorosulfoxide was slowly added dropwise and stirring was continued for 1 hour after completion of the dropwise addition. Subsequently, 6.00 g (57 mmol) of DL-serine was added to the reaction system. The reaction mixture was heated to reflux and the reaction was continued for 18 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The product was dried to give 8.32 g of DL-serine methyl ester hydrochloride in 94.2% yield. | [References]
[1] Heterocycles, 2012, vol. 86, # 2, p. 1575 - 1582
[2] Patent: CN105777611, 2016, A. Location in patent: Paragraph 0048; 0049
[3] Australian Journal of Chemistry, 1994, vol. 47, # 5, p. 903 - 912
[4] Journal of the Chemical Society. Perkin Transactions 2, 1997, # 3, p. 503 - 507
[5] Journal of the American Chemical Society, 2010, vol. 132, # 7, p. 2274 - 2283 |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-6106006 |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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