| Identification | More | [Name]
Quinestrol | [CAS]
152-43-2 | [Synonyms]
17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
17a-ethynylestradiol 3-cyclopentyl ether
17ALPHA-ETHYLNYL-1,3,5[10]ESTRATRIENE-3,17BETA-DIOL 3-CYCLOPENTYL ETHER
17ALPHA-ETHYNYLESTRADIOL-3-CYCLOPENTYL ETHER
QUINESTROL
17-alpha-ethinylestradiol3-cyclopentylether
3-(cyclopentyloxy)-(17-alpha)-19-norpregna-5(10)-trien-20-yn-17-ol
3-(cyclopentyloxy)-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol
5(10)-trien-20-yn-17-ol,3-(cyclopentyloxy)-19-nor-17-alpha-pregna-3
eecpe
eston
estradiol-17-beta3-cyclopentylether
estrovis
estrovis4000
estrovister
plestrovis
qui-lea
w3566
3-cyclopentyloxy-17-alpha-ethynyloestra-1,3,5(10)-trien-17-beta-ol
(17ALPHA-3-(CYCLOPENTYLOXY)-19-NORPREGNA-1,3,5(10)TRIENE-20-YN-17-OL | [EINECS(EC#)]
205-803-1 | [Molecular Formula]
C25H32O2 | [MDL Number]
MFCD00079189 | [Molecular Weight]
364.52 | [MOL File]
152-43-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
107-108° | [alpha ]
D25 +5° (c = 0.5 in dioxane) | [Boiling point ]
435.69°C (rough estimate) | [density ]
1.0693 (rough estimate) | [refractive index ]
1.4480 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.10±0.40(Predicted) | [color ]
White to Off-White | [Merck ]
14,8055 | [CAS DataBase Reference]
152-43-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R61:May cause harm to the unborn child.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
RC8948000
|
| Hazard Information | Back Directory | [Description]
Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy.1,2 It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications. | [Uses]
antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor | [Definition]
ChEBI: Quinestrol is a 17-hydroxy steroid and a terminal acetylenic compound. It has a role as a xenoestrogen. It is functionally related to a 17beta-estradiol. | [Brand name]
Estrovis (Parke-Davis). | [References]
[1]. baumgardner sb, condrea h, daane ta, et al. replacement estrogen therapy for menopausal vasomotor flushes. comparison of quinestrol and conjugated estrogens. obstet gynecol. 1978 apr;51(4):445-52.
[2]. skouby, s.o. criteria for the selection of an optimal estrogen replacement. gynecological endocrinology 15, 60-67 (2001).
[3]. li j, chen f, li c,et al. quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. tissue cell. 2014 oct;46(5):318-25.
[4]. li j, chen f, chen y, et al. mitochondrial- and fas-l-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. toxicol mech methods. 2014 dec;24(9):609-15. |
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