| Identification | Back Directory | [Name]
4-Hydroxytolbutamide | [CAS]
5719-85-7 | [Synonyms]
HYDROXY TOLBUTAMIDE
Tolbutamide Hydroxy
4-HYDROXYTOLBUTAMIDE
Tolbutamide Impurity 4
hydroxymethyltolbutamide
HydroxyMethylcarbutaMide
4-Hydroxytolbutamide solution
4-Hydroxytolbutamide Solution, 100ppm
1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea
1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea
N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide
N-(BUTYLAMINOCARBONYL)-4-HYDROXYMETHYLBENZENESULFONAMIDE
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-
4-Hydroxytolbutamide,N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide | [EINECS(EC#)]
200-835-2 | [Molecular Formula]
C12H18N2O4S | [MDL Number]
MFCD00144466 | [MOL File]
5719-85-7.mol | [Molecular Weight]
286.35 |
| Chemical Properties | Back Directory | [Melting point ]
100-102 °C | [density ]
1.268±0.06 g/cm3(Predicted) | [Fp ]
2℃ | [storage temp. ]
2-8°C | [solubility ]
ethanol: 12 mg/mL
| [form ]
Solid | [pka]
4.96±0.10(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Description]
4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs. | [Chemical Properties]
White Solid | [Uses]
A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes | [Definition]
ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position. | [storage]
Store at -20°C |
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