| Identification | More | [Name]
3-Aminobenzenesulfonamide | [CAS]
98-18-0 | [Synonyms]
3-AMINOBENZENE-1-SULFONAMIDE
3-AMINOBENZENESULFONAMIDE
BENZENESULFONAMIDE, 3-AMINO-
M-AMINOBENZENESULFONAMIDE
METANILAMIDE
3-amino-benzenesulfonamid
3-aminosulfonylaniline
Benzenesulfonamide, m-amino-
m-Aminobenzenesulphonamide
Metaniilamide
m-sulfamoylaniline
3-Aminobenzenesulphonamide
3-Aminobenzenesulfonamide97%
Benzenesulfonamide, 3-amino-(9CI)
Metanilic acid amide
3-AMINOBENZENESULFONAMIDE: TECH., 80%
3-Sulfanilamide | [EINECS(EC#)]
202-646-0 | [Molecular Formula]
C6H8N2O2S | [MDL Number]
MFCD00035781 | [Molecular Weight]
172.2 | [MOL File]
98-18-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
139 °C | [Boiling point ]
420.7±47.0 °C(Predicted) | [density ]
1.303 (estimate) | [refractive index ]
1.6490 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
10.34±0.60(Predicted) | [color ]
White to Light red to Green | [Water Solubility ]
11.96g/L(24 ºC) | [InChI]
InChI=1S/C6H8N2O2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) | [InChIKey]
JPVKCHIPRSQDKL-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=CC(N)=C1 | [CAS DataBase Reference]
98-18-0(CAS DataBase Reference) | [NIST Chemistry Reference]
m-Aminobenzenesulfonamide(98-18-0) | [EPA Substance Registry System]
98-18-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [RTECS ]
OY2200000 | [Hazard Note ]
Harmful/Irritant | [TSCA ]
Yes | [HS Code ]
29350090 |
| Hazard Information | Back Directory | [Chemical Properties]
Deep yellow powder | [Synthesis]
(a) 3-Nitrobenzenesulfonamide (1.0 g, 5 mmol) was suspended in 10 mL of methanol, followed by addition of tetrahydrofuran (THF) until the solid was completely dissolved. Ammonium acetate (1.45 g, 23 mmol) and 10% palladium/carbon catalyst (205 mg) were added sequentially at 0 °C. The reaction temperature was maintained at 0-5 °C until the gas release stopped completely. The reaction system was then warmed to room temperature and stirred continuously for 2 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the solid residue was washed well with THF. Concentration of the filtrate gave 3-aminobenzenesulfonamide as a white solid (810 mg, 93% yield), which could be used in subsequent reactions without further purification. MS (+ESI): 173.0 (M+H+). | [References]
[1] Patent: WO2009/39553, 2009, A1. Location in patent: Page/Page column 58-59
[2] Patent: WO2008/129080, 2008, A1. Location in patent: Page/Page column 156; 174
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 1, p. 28 - 33
[4] Patent: CN106543077, 2017, A. Location in patent: Paragraph 0069-0071
[5] Farmaco, Edizione Scientifica, 1959, vol. 14, p. 751,761 |
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