| Identification | Back Directory | [Name]
NISOXETINE HYDROCHLORIDE | [CAS]
57754-86-6 | [Synonyms]
LY-94,939
Nsc298819
NisoxetineHCl
NISOXETINE HYDROCHLORIDE
LY-94939; NSC298819; NISOXETINE HCL
4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE
(+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride
(±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
(+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE
LY-94,939, (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride | [Molecular Formula]
C17H22ClNO2 | [MDL Number]
MFCD00153850 | [MOL File]
57754-86-6.mol | [Molecular Weight]
307.82 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
H2O: 20 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble to 100 mM in water | [InChI]
InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H | [InChIKey]
LCEURBZEQJZUPV-UHFFFAOYSA-N | [SMILES]
C(CCNC)(OC1=CC=CC=C1OC)C1C=CC=CC=1.Cl |
| Hazard Information | Back Directory | [Uses]
Nisoxetine Hydrochloride is a selective and potent inhibitor of norepinephrine transporter. | [Biological Activity]
A potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors. | [Biochem/physiol Actions]
Nisoxetine?is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity. | [in vivo]
Nisoxetine (2.2 μM; a single intrathecal injection) hydrochloride shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3].
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride inhibits refeeding response (intake of standard chow) in rats[4].
| Animal Model: | Sprague-Dawley rats(290-340 g)[3] | | Dosage: | 0.6, 1.2, 1.8, 2.2 μM | | Administration: | A single intrathecal injection | | Result: | Showed ED50s of 0.82, 0.75 and 0.70 μM in blocking motor function, proprioception, and nociception respectively. |
| [storage]
Store at RT |
|
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