| Identification | More | [Name]
Closantel | [CAS]
57808-65-8 | [Synonyms]
5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE
CLOSANTEL
CLOSANTEL BASE
N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE
n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid
5-diiodo-y-
benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox
faskoverm
iodobenzamide
n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di
Closantelfreebase
N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE
Benzamide, N-5-chloro-4-(4-chlorophenyl)cyanomethyl-2-methylphenyl-2-hydroxy-3,5-diiodo-
5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide
CLOSANTEL(PATENT)
N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)
N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide
Diantel
N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide | [EINECS(EC#)]
260-967-1 | [Molecular Formula]
C22H14Cl2I2N2O2 | [MDL Number]
MFCD00661151 | [Molecular Weight]
663.07 | [MOL File]
57808-65-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
217.8° | [Boiling point ]
590.5±50.0 °C(Predicted) | [density ]
1.8759 (estimate) | [storage temp. ]
0-6°C
| [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | [form ]
neat | [pka]
5.99±0.48(Predicted) | [color ]
White to off-white | [Major Application]
agriculture
environmental | [InChI]
1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30) | [InChIKey]
JMPFSEBWVLAJKM-UHFFFAOYSA-N | [SMILES]
Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O | [CAS DataBase Reference]
57808-65-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H413 | [Precautionary statements ]
P273-P301+P310+P330 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [RIDADR ]
2811 | [WGK Germany ]
3 | [RTECS ]
CV2444250 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Chronic 4 | [Toxicity]
A veterinary drug for the treatment of fluke and
nematode infestations. In 1993, some was included in a batch
of donated drugs sent to Lithuania. Attempts to match the
product with the names of other medicines on accompanying
literature resulted in its misidentification as a treatment for
endometriosis. Eleven women lost their eyesight; though this
has since returned, they were left with eye pain and are unable
to work. |
| Questions And Answer | Back Directory | [Description]
Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.
| [References]
http://www.interchemie.com/veterinary-medicines/closan-50.html
|
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow powder | [Uses]
antianginal, antihypertensive | [Definition]
ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes. |
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