582-83-2

462-06-6

141-75-3

582-83-2

In a 500 mL four-necked flask, n-butyryl chloride (55.5 g, 0.52 mol) was dissolved in ethylene dichloride (250 mL), stirred well, and cooled to about 10°C. Fluorobenzene (52.1 g, 0.57 mol) was dissolved in 100 mL of ethylene dichloride, prepared as a solution and then slowly added dropwise to the n-butyryl chloride solution. After the dropwise addition was completed, the reaction mixture was heated and the reaction process was monitored by thin layer chromatography (TLC) or gas chromatography (GC). Upon completion of the reaction, the reaction solution was poured into a mixture of dilute hydrochloric acid and ice, stirred for 1 hour, and left to stratify. The organic phase was separated and washed sequentially with water and saturated sodium carbonate solution. The solvent was removed by distillation under reduced pressure, and the fraction at 102~105°C/9 mmHg was collected to give 77.8 g of 4-fluorobutyrophenone in 90% yield and 99.0% purity.