| Identification | More | [Name]
6-CHLORONICOTINOYL CHLORIDE | [CAS]
58757-38-3 | [Synonyms]
6-CHLORONICOTINOYL CHLORIDE
6-CHLORONICOTINYL CHLORIDE
6-CHLOROPYRIDINE-3-CARBONYL CHLORIDE
BUTTPARK 96\50-26
6-Chloronicotinoylchloride,98%
3-Pyridinecarbonyl chloride, 6-chloro-(9CI)
2-CHLOROPYRIDINE-5-CARBONYL CHLORIDE
6-Chloronicotinoyl Chlorid | [Molecular Formula]
C6H3Cl2NO | [MDL Number]
MFCD00051775 | [Molecular Weight]
176 | [MOL File]
58757-38-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
48-51 °C(lit.) | [Boiling point ]
84-85°C 3mm | [density ]
1.454±0.06 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
soluble in Toluene | [form ]
Solid | [pka]
-2.65±0.10(Predicted) | [color ]
White to off-white | [Sensitive ]
Moisture Sensitive | [BRN ]
115927 | [CAS DataBase Reference]
58757-38-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Uses]
6-Chloronicotinoyl chloride serves as an acylating agent for synthesizing N-(6-chloronicotinoyl)-β-aminobutyric acid via Schotten–Baumann reaction with β-aminobutyric acid and NaOH at –7 to –5°C, yielding the product in over 60% yield[1]. The reagent acylates steroidal substrates, including 3β,5α,6β-trihydroxysteroids, 3β,5-dihydroxy-6-ketosteroids, and 20-hydroxyecdysone (in pyridine at room temperature), to produce new esters containing 6-chloropyridine groups[2][3]. | [Synthesis]
6-Chloronicotinoyl chloride is prepared by reacting 6-methoxynicotinic acid with thionyl chloride in refluxing DMF, followed by vacuum distillation to afford the product in high yield[2]. | [References]
[1]Kovganko, N. V., Sokolov, S. N., & Chernov, Y. G. (2011). Synthesis of α-chloropyridine derivatives of γ-aminobutyric acid. Chemistry of Natural Compounds, 47(5), 781–782. https://doi.org/10.1007/s10600-011-0057-4
[2]Kovganko, N. V., Chernov, Y. G., Sokolov, S. N., Kashkan, Z. N., & Survilo, V. L. (2009). Synthesis of 6-chloronicotinates of steroidal 3β,5α,6β-triols and 3β,5-dihydroxy-6-ketones. Chemistry of Natural Compounds, 45(2), 200–204. https://doi.org/10.1007/s10600-009-9265-6
[3]Bobaev, I. D., Kovganko, N. V., Chernov, Y. G., Utaeva, Z. R., Sokolov, S. N., Kashkan, Z. N., & Ramazanov, N. S. (2009). Synthesis of 20-hydroxyecdysone 6-chloronicotinates. Chemistry of Natural Compounds, 45(3), 385–388. https://doi.org/10.1007/s10600-009-9338-6 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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