| Identification | More | [Name]
2,4-Dihydroxy-6-methylpyrimidine | [CAS]
626-48-2 | [Synonyms]
2,4-DIHYDROXY-6-METHYL PYRIMIDE
2,4-DIHYDROXY-6-METHYLPYRIMIDINE
4-METHYLURACIL
6-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
6-METHYL-1,2,4-DIHYDROXYPYRIMIDINE
6-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE
6-METHYLPYRIMIDINE-2,4-DIOL
6-METHYLURACIL
AURORA KA-4132
METHYLURACIL, 6-
TIMTEC-BB SBB004254
TIMTEC-BB SBB004256
2(1H)-Pyrimidinone, 4-hydroxy-6-methyl-
2,4(1H,3H)-Pyrimidinedione, 6-methyl-
2,4(1H,3H)-Pyrimidinedione,6-methyl-
2,4-Pyrimidinediol, 6-methyl-
3h)-pyrimidinedione,6-methyl-4(1h
4(1H,3H)-Pyrimidinedione,6-methyl-2
4-(6)-Methyluracil
6-Methyl-1H-pyrimidine-2,4-dione | [EINECS(EC#)]
210-949-4 | [Molecular Formula]
C5H6N2O2 | [MDL Number]
MFCD00006028 | [Molecular Weight]
126.11 | [MOL File]
626-48-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Crystalline Solid | [Melting point ]
318 °C (dec.)(lit.)
| [density ]
1.226±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
Fine Crystalline Powder | [pka]
pK1:9.52 (25°C) | [color ]
White to almost white | [Water Solubility ]
7 g/L (22 ºC) | [Detection Methods]
HPLC,NMR | [Merck ]
14,6133 | [BRN ]
115647 | [InChI]
InChI=1S/C5H6N2O2/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9) | [InChIKey]
SHVCSCWHWMSGTE-UHFFFAOYSA-N | [SMILES]
C1(=O)NC(C)=CC(=O)N1 | [CAS DataBase Reference]
626-48-2(CAS DataBase Reference) | [NIST Chemistry Reference]
6-Methyluracil(626-48-2) | [EPA Substance Registry System]
626-48-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [Hazard statements ]
H361 | [Precautionary statements ]
P281 | [Hazard Codes ]
Xn | [Risk Statements ]
R62:Possible risk of impaired fertility.
R63:Possible risk of harm to the unborn child. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
1759 | [WGK Germany ]
3
| [RTECS ]
YR0700000
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29335995 | [Safety Profile]
Moderately toxic by
ingestion. Questionable carcinogen with
experimental neoplastigenic and teratogenic
data. Experimental reproductive effects.
When heated to decomposition it emits
toxic fumes of NOx. | [Hazardous Substances Data]
626-48-2(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 64500mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Urea-->Methyl acetoacetate-->Methylthiouracil-->4-Methyl-2,6-bis(methylsulfanyl)pyrimidine-->2,4-Imidazolidinedione, 1-acetyl-5-hydroxy- (9CI)-->1,3-dibenzyl-6-methylpyrimidine-2,4(1H,3H)-dione-->Bz-Ala-OMe-->Butyl benzoate-->N,N-Diethylbenzamide-->N-Allylmethylamine | [Preparation Products]
2,8-Dichloropyrimido[5,4-d]pyrimidine-->Orotic acid-->4,5-Diamino-6-methylpyrimidine-->2,4-Bis(dimethylamino)pyrimidine-6-carboxylic acid-->5-Nitro-6-methyluracil-->CRIMIDINE-->2,4-Dichloro-6-methyl-5-nitropyrimidine-->Potassium orotate-->4-Amino-2-chloro-6-methyl-5-nitropyrimidine-->6-Carboxy-2,4-dihydroxypyrimidine monosodium salt-->6-Formyl-uracil monohydrate-->4-Hydroxy-6-methylpyrimidine |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Crystalline Solid | [Uses]
6-Methyluracil (cas# 626-48-2) is a compound useful in organic synthesis. | [Definition]
ChEBI: A pyrimidone that is uracil with a methyl group at position 6. | [Preparation]
6-Methyluracil [626-48-2]. is produced by condensation of diketene with urea. It is used in the production of the analgesic mepirizole, the feed additive orotic acid, and 5-aminoorotic acid. | [Purification Methods]
Crystallise 6-methyluracil from EtOH or acetic acid. [Beilstein 24 III/IV 1281.] |
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