| Identification | More | [Name]
2-Methoxyethyl chloride | [CAS]
627-42-9 | [Synonyms]
1-CHLORO-2-METHOXYETHANE
2-CHLOROETHYL METHYL ETHER
2-METHOXYETHYL CHLORIDE
CHLOROETHYL METHYL ETHER
1-chloro-2-methoxy-ethan
beta-chloroethylmethylether
Ethane, 1-chloro-2-methoxy-
ethane,1-chloro-2-methoxy
ether,2-chloroethylmethyl
Chloro-2-methoxyethane
2-Methoxyethylchlorid
Ethyleneglycol monomethyl ether chloride
1-Methoxy-2-chloroethane | [EINECS(EC#)]
210-999-7 | [Molecular Formula]
C3H7ClO | [MDL Number]
MFCD00000972 | [Molecular Weight]
94.54 | [MOL File]
627-42-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellowish liquid | [Melting point ]
-55 °C
| [Boiling point ]
89-90 °C (lit.) | [density ]
1.035 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.408(lit.)
| [Fp ]
59 °F
| [storage temp. ]
Flammables area | [solubility ]
80g/l | [form ]
Liquid | [color ]
Clear colorless to yellow | [Water Solubility ]
60 g/L (20 C) | [BRN ]
1731028 | [Stability:]
Volatile | [InChI]
1S/C3H7ClO/c1-5-3-2-4/h2-3H2,1H3 | [InChIKey]
XTIGGAHUZJWQMD-UHFFFAOYSA-N | [SMILES]
COCCCl | [CAS DataBase Reference]
627-42-9(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Chloroethyl methyl ether(627-42-9) | [EPA Substance Registry System]
627-42-9(EPA Substance) |
| Questions And Answer | Back Directory | [Uses]
2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H302-H315 | [Precautionary statements ]
P210-P301+P312+P330-P302+P352 | [Hazard Codes ]
F,Xn | [Risk Statements ]
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R22:Harmful if swallowed. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3271 3/PG 2
| [WGK Germany ]
3
| [F ]
9 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29091900 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Flam. Liq. 2
Skin Irrit. 2 | [Hazardous Substances Data]
627-42-9(Hazardous Substances Data) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Methanol, chloro--->Dichloramine B-->2,2'-Dichlorodiethyl ether-->Dimethyl sulfate-->Trimethyloxonium Tetrafluoroborate-->2-Chloroethanol-->1,4-Dichlorobutane | [Preparation Products]
1-(2-Methoxyethyl)piperazine-->Bis(2-methoxyethyl)amine-->Chloromethane-->1,4-Dioxane-->1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->4-(2-Methoxyethoxy)aniline-->Tris(2-(2-methoxyethoxy)ethyl)amine-->4-(2-methoxyethoxy)benzonitrile-->1,4-Di-t-butyl-2,5-bis(2-methoxyethoxy)benzene, 99+% Redox shuttle ANL-RS2-->1-(2-methoxyethyl)-1H-imidazole-->Benzene, 1-chloro-2-(2-methoxyethoxy)-4-nitro--->1-(2-Methoxyethyl)benzimidazole |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to yellowish liquid | [Synthesis]
To a round-bottomed flask equipped with a distillation apparatus, calcium carbonate (27.3 g, 273.2 mmol), dimethyl sulfate (23.5 mL, 248.4 mmol) and 2-chloroethanol (16.6 mL, 248.4 mmol) were added sequentially. The reaction mixture was heated to 120-130°C and the reaction was continued until distillation ceased (about overnight). After completion of the reaction, the distillate was diluted with ether and washed with 2N NaOH solution. The aqueous layer was again extracted with ether, and all ether layers were combined and dried with anhydrous magnesium sulfate (MgSO?). Finally, the target product 2-chloroethyl methyl ether (16) was obtained as a colorless liquid by conventional distillation (collection of fractions with a vapor temperature of 88-90°C). Yield: 10.2 g, 43% yield. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1784 - 1788
[2] Journal of the American Chemical Society, 1924, vol. 46, p. 2530
[3] Journal of the American Chemical Society, 1924, vol. 46, p. 2530 |
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