| Identification | More | [Name]
2-Chloroquinoline | [CAS]
612-62-4 | [Synonyms]
2-CHLOROQUINOLINE
2CQ
2-chloro-quinolin
Quinoline2-chloro-
2-Chloroquinoline,99% | [EINECS(EC#)]
210-317-8 | [Molecular Formula]
C9H6ClN | [MDL Number]
MFCD00006741 | [Molecular Weight]
163.6 | [MOL File]
612-62-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to yellowish crystals, powder, chunks or | [Melting point ]
34-37 °C (lit.) | [Boiling point ]
266-267 °C (lit.) | [density ]
1.23 g/mL at 25 °C(lit.)
| [refractive index ]
1.6342 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
methanol: 0.1 g/mL, clear
| [form ]
Crystalline Powder, Crystals and/or Chunks or Fused Mass | [pka]
0.41±0.40(Predicted) | [color ]
White to yellow | [Water Solubility ]
Insoluble | [BRN ]
112561 | [InChI]
1S/C9H6ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H | [InChIKey]
OFUFXTHGZWIDDB-UHFFFAOYSA-N | [SMILES]
Clc1ccc2ccccc2n1 | [CAS DataBase Reference]
612-62-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Quinoline, 2-chloro-(612-62-4) | [EPA Substance Registry System]
612-62-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
VB2320000
| [F ]
8 | [TSCA ]
Yes | [HS Code ]
29334900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to yellowish crystals, powder, chunks or | [Uses]
2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196i
Synthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152 | [Synthesis]
In a dry four-necked reaction flask add 20mL of dichloromethane, add 2.175g (15mmol) of quinoline N-oxide, turn on the stirring, cool to 0°C add 3.035g (30mmol) of triethylamine, the temperature of the system is controlled below -5°C, add 0.438g (7.5mmol) | [Purification Methods]
Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.] |
|
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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