| Identification | More | [Name]
Fumaryl chloride | [CAS]
627-63-4 | [Synonyms]
FUMAROYL DICHLORIDE
FUMARYL CHLORIDE
FUMARYL DICHLORIDE
trans-Butenedioyl chloride
(2E)-2-Butenedioyl dichloride
(E)-1,4-Dioxo-2-butenyldichloride
(e)-2-butenedioyldichlorid
(E)-butenedioyldichloride
2-Butenedioyl dichloride, (E)-
Chlorure de fumaryle
chloruredefumaryle
Dichlorid kyseliny fumarove
dichloridkyselinyfumarove
Fumaroyl chloride
fumaroylchloride
fumaryl
Fumarylchlorid
TL 189
tl189
trans-2-Butenedioyl dichloride | [EINECS(EC#)]
211-005-4 | [Molecular Formula]
C4H2Cl2O2 | [MDL Number]
MFCD00000733 | [Molecular Weight]
152.96 | [MOL File]
627-63-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear yellow liquid | [Melting point ]
-2 °C
| [Boiling point ]
161-164 °C(lit.)
| [density ]
1.415 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.499(lit.)
| [Fp ]
165 °F
| [storage temp. ]
Refrigerator (+4°C) | [form ]
Liquid | [color ]
Clear yellow | [Specific Gravity]
1.415 (20/4℃) | [Water Solubility ]
decomposes | [Sensitive ]
Moisture Sensitive | [BRN ]
1721342 | [InChIKey]
ZLYYJUJDFKGVKB-OWOJBTEDSA-N | [Uses]
Chemical intermediate for pharmaceuticals,
dyestuffs, and insecticides. | [CAS DataBase Reference]
627-63-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Fumaryl chloride(627-63-4) | [EPA Substance Registry System]
627-63-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R37:Irritating to the respiratory system.
R29:Contact with water liberates toxic gas.
R36/37:Irritating to eyes and respiratory system .
R14:Reacts violently with water. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S8:Keep container dry .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 1780 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
LT2800000
| [F ]
21 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29171990 | [Safety Profile]
Moderately toxic by
ingestion, inhalation, and skin contact. A
skin, eye, and mucous membrane irritant. A
corrosive agent. Will react with water or
steam to produce toxic and corrosive fumes.
When heated to decomposition it emits
highly toxic fumes of phosgene and HCl. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Thionyl chloride-->Phosphorus pentachloride-->Zinc chloride-->CIS-BUTENEDIOIC ANHYDRIDE-->Fumaric acid-->Phthaloyl dichloride | [Preparation Products]
TRANS-1,2-DIBENZOYLETHYLENE-->2,4-DIBROMOMESITYLENE-->(E)-2,2'-vinylenebis[5-methylbenzoxazole]-->BIS(2,2,2-TRIFLUOROETHYL)MALEATE-->(Z)-4-((4-acetamidophenyl)amino)-4-oxobut-2-enoic acid-->2-Butene-1,4-dione,1,4-bis(4-chlorophenyl)--->Dyclonine Impurity 3-->bis(2,4,6-tribromophenyl) fumarate |
| Hazard Information | Back Directory | [General Description]
A straw colored fuming liquid with a pungent odor. Flash point 165°F. Vapors irritate the eyes and mucous membranes. Corrosive to metals and tissue. | [Reactivity Profile]
FUMARYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines and other bases. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Hazard]
Corrosive to eyes and skin. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [Chemical Properties]
Clear yellow liquid | [Preparation]
Fumaryl chloride has been prepared from fumaric acid and phthaloyl chloride, from maleic acid by the action of thionyl chloride in the presence of zinc chloride, and from maleic anhydride by the use of phthaloyl chloride in the presence of zinc chloride.
Org. Synth. 1940, 20, 51
DOI: 10.15227/orgsyn.020.0051 |
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