| Identification | More | [Name]
1,7-DIAMINOHEPTANE | [CAS]
646-19-5 | [Synonyms]
1,7-DIAMINOHEPTANE
1,7-HEPTANEDIAMINE
HEPTAMETHYLENEDIAMINE
HEPTANEDIAMINE
RARECHEM AL BW 0083
1,7-Heptamethylenediamine
H2N(CH2)7NH2
Diaminoheptane
Heptamethylenediamine~1,7-Heptanediamine
1,7-Diaminoheptane,98%
1,7-Heptanediamine, Heptamethylenediamine
Heptane-1,7-diamine | [EINECS(EC#)]
211-468-2 | [Molecular Formula]
C7H18N2 | [MDL Number]
MFCD00008246 | [Molecular Weight]
130.23 | [MOL File]
646-19-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystalline chunks | [Melting point ]
26-29 °C (lit.) | [Boiling point ]
223-225 °C (lit.) | [density ]
0,86 g/cm3 | [Fp ]
190 °F
| [refractive index ]
1.4590 | [storage temp. ]
2-8°C
| [solubility ]
450g/l | [form ]
Crystalline Chunks | [pka]
10.95±0.10(Predicted) | [color ]
White to light yellow | [Water Solubility ]
Soluble in water, ethanol, acetone, ether and benzene. | [Sensitive ]
Air Sensitive | [BRN ]
1734159 | [CAS DataBase Reference]
646-19-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
Step 1 involves the hydroxylation of cycloheptane to cycloheptanol, catalyzed by enzyme p450 in the presence of the endogenous cofactor NADPH. Step 2 involves the oxidation of cycloheptanol to cycloheptanone, catalyzed by alcohol dehydrogenase (ADH) in the presence of NADP+, followed by the conversion of cycloheptanone to heptanolide by Baeyer-Villiger oxidase (BVMO). Heptanolide is then hydrolyzed by lactonease (Lac) to 7-hydroxyheptanoic acid, which is subsequently reduced to 1,7-heptanediol by CAR (with the aid of phosphoethyl ester transferase (SFP)) and endogenous aldehyde-ketone reductase (AKR). Step 3 involves two rounds of oxidation/amination reactions catalyzed by ChnD and TA: first, 1,7-heptanediol is oxidized to 7-hydroxyheptanal by ChnD, then amination with TA to 7-aminoheptanol, then oxidized again by ChnD to 7-aminoheptanal, and finally amination with TA to 1,7-diaminoheptane. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3259 8/PG 2
| [WGK Germany ]
3
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29212900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystalline chunks | [Uses]
1,7-Diaminoheptane is used in the preparation of 7-amino-1-guanidinooctane and 1,7-diamino-trans-hept-3-ene, which is used as a deoxyhypusine synthase inhibitor. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|