| Identification | Back Directory | [Name]
2-Acetyl-3-methyl-5-methoxyphenol | [CAS]
6540-66-5 | [Synonyms]
Acetoevernone
2-Acetyl-3-methyl-5-methoxyphenol
1-(2-Hydroxy-4-methoxy-6-methylphenyl)ethanone
Ethanone, 1-(2-hydroxy-4-methoxy-6-methylphenyl)- | [Molecular Formula]
C10H12O3 | [MOL File]
6540-66-5.mol | [Molecular Weight]
180.2 |
| Hazard Information | Back Directory | [Uses]
6’-Methyl paeonol is a paeonol derivative, which inihibits abnormal depolarizations and reduces the Amyloid β-induced ERK phosphorylation. 6’-Methyl paeonol exhibits alleviating activity against Alzheimer’s Disease[1]. | [Preparation]
Preparation by partial methylation of 2,4-dihydroxy-6-methylacetophenone (orcacetophenone or b-orcacetophenone), with diazomethane (78%) or dimethyl sulfate. | [in vivo]
6’-Methyl paeonol (20 mg/kg, s.c.) ameliorates the impairment of memory and learning behavior in J20 mice[1]. | Animal Model: | APP transgenic C57BL/6 mice (J20 mice)[1] | | Dosage: | 20 mg/kg | | Administration: | subcutaneous injection | | Result: | Reduced the time for mice reaching hidden platform. |
| [References]
[1] Chen PJ, et al., Derivative, 6'-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer's Disease Mice Model. ACS Chem Neurosci. 2024 Feb 21;15(4):724-734. DOI:10.1021/acschemneuro.3c00633 |
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