| Identification | Back Directory | [Name]
Fazarabine | [CAS]
65886-71-7 | [Synonyms]
ara-AC
NSC-281272
Fazarabine
4-Amino-1-β-D-arabinofuranosyl-1,3,5-triazin-2(1H)-one
1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl-
4-amino-1-beta-D-arabinofuranosyl-1,3,5-triazin-2(1H)-one
4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one | [Molecular Formula]
C8H12N4O5 | [MOL File]
65886-71-7.mol | [Molecular Weight]
244.2 |
| Chemical Properties | Back Directory | [Melting point ]
220 °C (decomp) | [Boiling point ]
534.5±60.0 °C(Predicted) | [density ]
2.08±0.1 g/cm3(Predicted) | [pka]
13.46±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antineoplastic. | [Definition]
ChEBI: Fazarabine is an N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-arabinofuranosyl residue via an N-glycosidic linkage. A synthetic analogue of cytosine arabinoside and 5-azacytidine that incorporates structural features of both compounds, it shows good activity against a variety of transplanted tumors. It has a role as an antineoplastic agent. It is a N-glycosyl-1,3,5-triazine and a nucleoside analogue. It is functionally related to a beta-D-arabinofuranose. |
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