| Identification | Back Directory | [Name]
5,4'-DIHYDROXYFLAVONE | [CAS]
6665-67-4 | [Synonyms]
5-Dihydroxyflavone
4',5-DIHYDROXYFLAVONE
5,4'-DIHYDROXYFLAVONE
5-Hydroxy-2-(4-hydroxyphenyl)
5-Hydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-
Lipoxygenase,Glucosidase,LOX,4',5-Dihydroxyflavone,4',5 Dihydroxyflavone,inhibit,Inhibitor,4',5Dihydroxyflavone | [Molecular Formula]
C15H10O4 | [MDL Number]
MFCD00017691 | [MOL File]
6665-67-4.mol | [Molecular Weight]
254.24 |
| Chemical Properties | Back Directory | [Melting point ]
239-240°C | [Boiling point ]
486.0±45.0 °C(Predicted) | [density ]
1.443±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 155 mg/mL (609.66 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
6.78±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1. | [References]
[1] Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45. DOI:10.1016/j.ejmech.2013.11.030
[2] Proen?a C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228. DOI:10.1080/14756366.2017.1368503 |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
sgtlifesciences pvt ltd
|
| Telephone: |
+91-8790379245 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList1846349/0.htm |
|