| Identification | Back Directory | [Name]
Polygalacin D | [CAS]
66663-91-0 | [Synonyms]
Polygalacin D
Onjisaponin D
Polygalacin D2
Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)- | [Molecular Formula]
C57H92O27 | [MDL Number]
MFCD28009141 | [MOL File]
66663-91-0.mol | [Molecular Weight]
1209.34 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
12.76±0.70(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
White needle crystal. Soluble in water, ethanol, methanol and other solvents, insoluble in petroleum ether, chloroform, ethyl acetate. | [Definition]
ChEBI: Polygalacin D is a triterpenoid saponin. It has a role as a metabolite. | [Biological Activity]
Polygalacin D (PGD) is a bioactive compound with anticancer and antiproliferative properties isolated from Platycodon grandiflorum. It inhibits the expression of the IAP protein family, including survivin, cIAP-1 and cIAP-2 proteins, and blocks the PI3K/Akt pathway by inhibiting GSK3β, Akt phosphorylation and PI3K expression. It induces apoptosis through the PI3K/Akt pathway. | [target]
NOS | COX | PGE | NO | NF-kB | [storage]
4°C, protect from light |
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