| Identification | Back Directory | [Name]
Zonisamide sodium salt | [CAS]
68291-98-5 | [Synonyms]
ZON
ZonisaMide (sodiuM)
Zonisamide sodium salt
Exceglan sodium-potassium salt
Excegram sodium-potassium salt
Aleviatin sodium-potassium salt
1,2-BENZISOXAZOLE-3-METHANESULFONAMIDE
BENZO[D]ISOXAZOL-3-YL-METHANESULFONAMIDE
1,2-Benzisoxazole-3-methanesulfonamide sodium salt
1,2-benzisoxazole-3-methanesulfonamide sodium-potassium salt
1,2-Benzisoxazole-3-methanesulfonamide sodium-potassium salt, Aleviatin sodium-potassium salt, Exceglan sodium-potassium salt, Excegram sodium-potassium salt | [Molecular Formula]
C8H7N2NaO3S | [MDL Number]
MFCD00865316 | [MOL File]
68291-98-5.mol | [Molecular Weight]
234.21 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
H2O: >5mg/mL | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: >5mg/mL | [InChI]
1S/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1 | [InChIKey]
ZVBIRPKGWOVBLG-UHFFFAOYSA-N | [SMILES]
[Na]NS(=O)(=O)Cc1noc2ccccc12 |
| Hazard Information | Back Directory | [Uses]
Zonisamide Sodium Salt can be used in biological study of neuroprotective effects of zonisamide target astrocyte. It shows neuroprotection by increasing glutathione, cystine/glutamate exchange transporter expression in mouse CNS catecholaminergic, astrocyte and rat glioma cell and mouse model of 6-OHDA induced hemi-Parkinson''s disease | [Biochem/physiol Actions]
Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO). | [in vivo]
Zonisamide sodium (40 mg/kg; i.p.; single daily for 14 days) prevents seizures in FeCl3-induced chronic amygdalar seizures model[2].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) alleviates cardiac hypertrophy and improved cardiac function in rats subjected to AAC (abdominal aortic constriction)[3].
Zonisamide sodium (14, 28, 56 mg/kg; i.p.; single daily for 6 weeks) upregulates Hrd1 expression and accelerates ERAD in the hearts of AAC rats[3]. | Animal Model: | Male Wistar rats (200-250 g; FeCl3-induced chronic amygdalar seizures)[2]. | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; single daily for 14 days. | | Result: | Showed activity of anti-seizures.
Significantly down-regulated GABA transporters GAT-1 in the hippocampus.
|
| Animal Model: | Adult male Sprague-Dawley rats (100-120 g; cardiac hypertrophy model)[3]. | | Dosage: | 14, 28, 56 mg/kg (dissolved in 1% DMSO) | | Administration: | Intraperitoneal injection; single daily for 6 weeks. | | Result: | Significantly attenuated cardiac hypertrophy and fibrosis.
Increased LV ejection fraction (EF), fractional shortening (FS) and E/A ratio.
Markedly increased the expression of Hrd1 in the hearts of AAC rats.
|
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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