| Identification | More | [Name]
2-Chloro-5-trichloromethylpyridine | [CAS]
69045-78-9 | [Synonyms]
2-CHLORO-5-TRICHLOROMETHYL PYRIDINE
AKOS BBS-00000412
IFLAB-BB F0797-0001 | [EINECS(EC#)]
614-911-1 | [Molecular Formula]
C6H3Cl4N | [MDL Number]
MFCD00160145 | [Molecular Weight]
230.91 | [MOL File]
69045-78-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN2811 | [Hazard Note ]
Irritant | [TSCA ]
TSCA listed | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Synthesis]
A synthetic method of 2-chloro-5-trichloromethyl pyridine comprises the following steps of (1) synthesis of N-oxygen-3-methylpyridine: reacting by taking 3-methylpyridine as a raw material, glacial acetic acid as a solvent and 60% hydrogen peroxide as an oxidizing agent to obtain N-oxygen-3-methylpyridine; (2) synthesis of 2-chloro-5-methylpyridine: carrying out oriented chlorination on N-oxygen-3-methylpyridine by taking benzoyl chloride as a chlorinating agent to obtain 2-chloro-5-methylpyridine; (3) synthesis of 2-chloro-5-trichloromethyl pyridine: reacting by taking methyl ethyl ketone peroxide as an initiating agent to obtain a crude 2-chloro-5-trichloromethyl pyridine product; (4) refining of 2-chloro-5-trifluoromethyl pyridine: carrying out halogen exchange fluoridation reaction by taking excessive potassium fluoride as a fluorizating agent, dimethyl sulfoxide as a solvent and hexadecyl trimethyl ammonium bromide as a phase transfer catalyst, and rectifying and purifying to obtain a fine 2-chloro-5-trichloromethyl pyridine product. |
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