| Identification | Back Directory | [Name]
Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- | [CAS]
698346-43-9 | [Synonyms]
84-B10
5-((2-(4-Methoxyphenoxy)-5-(trifluoromethyl)phenyl)amino)-5-oxo-3-phenylpentanoic acid
Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- | [Molecular Formula]
C25H22F3NO5 | [MOL File]
698346-43-9.mol | [Molecular Weight]
473.45 |
| Chemical Properties | Back Directory | [Boiling point ]
614.1±55.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
4.46±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. | [in vivo]
84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice[1]. | Animal Model: | Male C57BL/6 mice with acute kidney injury[1] | | Dosage: | 5, 10, and 15 mg/kg | | Administration: | intraperitoneal injection | | Result: | Decreased the sCr and BUN levels of cisplatin-exposed mice.
Attenuated renal tubules morphological abnormalities in a dose-dependent manner.
Decreased NGAL and KIM-1 levels in a dose-dependent manner.
Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.
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| [References]
[1] Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98. DOI:10.1016/j.freeradbiomed.2022.11.029 |
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Biorbyt Ltd.
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