| Identification | More | [Name]
Trimethyl orthobenzoate | [CAS]
707-07-3 | [Synonyms]
TRIMETHYL-O-BENZOATE
TRIMETHYL ORTHOBENZOATE
(trimethoxymethyl)-benzen
(Trimethoxymethyl)benzene
Methyl orthobenzoate
Orthobenzoic acid, trimethyl ester
Thrimethyl orthobenzoate
Benzene, (trimethoxymethyl)-
à,à,à-trimethoxytoluene
Phenylorthoformic acid trimethyl ester
Phenyltrimethoxymethane
Trimethoxyphenylmethane | [EINECS(EC#)]
211-897-5 | [Molecular Formula]
C10H14O3 | [MDL Number]
MFCD00008474 | [Molecular Weight]
182.22 | [MOL File]
707-07-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29163100 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067 | [General Description]
Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide. |
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