| Identification | More | [Name]
2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID | [CAS]
7113-10-2 | [Synonyms]
2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
2-PHENYLTHIAZOLE-4-CARBOXYLIC ACID
BUTTPARK 98\12-39
RARECHEM AL BE 1318
2-Phenyl-1,3-thiadiazole-4-carboxylic acid
2-Phenylthiazole-4-carboxylic acid ,97% | [Molecular Formula]
C10H7NO2S | [MDL Number]
MFCD00141954 | [Molecular Weight]
205.23 | [MOL File]
7113-10-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID was synthesized from benzaldehyde via a one-pot reaction with methyl 3-(dimethylamino)-2-isocyanoacrylate. This method features mild reaction conditions, high purity, simple operation, and no catalyst required, and can assemble various functional groups into the molecule. 
Synthetic reaction formula of 2-phenyl-1,3-thiazolyl-4-carboxylic acid Experimental procedure: Synthesis of methyl 2-phenyl-1,3-thiazolyl-4-carboxylate Benzaldehyde, methyl 3-(dimethylamino)-2-isocyanoacrylate, and anhydrous methanol were added sequentially to a reaction flask. Anhydrous magnesium sulfate was added with stirring, and the mixture was cooled in an ice-water bath and reacted at 0℃ for 2 h. The temperature was then raised to 30℃ and reacted for 16 h. The solvent was evaporated under vacuum to obtain methyl 2-phenyl-1,3-thiazolyl-4-carboxylate. Synthesis of 2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID: Methyl 2-phenyl-1,3-thiazol-4-carboxylate, aqueous lithium hydroxide solution, and methanol were added sequentially to a reaction flask, and the mixture was reacted at 30°C for 6 h with stirring. The solvent was removed under vacuum, the pH was adjusted to 3-5 with dilute hydrochloric acid, and the mixture was extracted with dichloromethane (2 × 50 mL). The extracts were combined, concentrated, and purified by silica gel column chromatography [eluent: V(dichloromethane):V(methanol) = 15:1] to obtain 2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID. | [Uses]
2-Phenylon-1,3-Thiazol-4-carboxylic acid, as a derivative of thiazol-4-carboxylic acid, is widely used in the pharmaceutical and chemical industries. Thiazol-4-carboxylic acid is a key intermediate in the synthesis of thiabendazole, one of the earliest benzimidazole drugs developed. It was successfully developed by Merck & Co., Inc. in 1968. Thiabendazole has a wide range of applications, mainly as an antiparasitic drug, bactericide, and preservative. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29349990 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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