| Identification | Back Directory | [Name]
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine | [CAS]
7139-02-8 | [Synonyms]
Einecs 230-437-4
Dipyridamole Impurity 7
Dipyridamole Impurity 7（Dipyridamole EP Impurity G）
2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
PyriMido[5,4-d]pyriMidine,2,6-dichloro-4,8-di-1-piperidinyl-
2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine
2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine
2,6-Dichloro-4,8-di-(piperidin-l-yl)pyrimido[5,4-d] pyrimidine
2,6-dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine (DCDPP)
2,6-DICHLORO-4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINEDIPYRIDAMOLE
Dipyridamole EP Impurity GQ: What is
Dipyridamole EP Impurity G Q: What is the CAS Number of
Dipyridamole EP Impurity G Q: What is the storage condition of
Dipyridamole EP Impurity G Q: What are the applications of
Dipyridamole EP Impurity G | [EINECS(EC#)]
230-437-4 | [Molecular Formula]
C16H20Cl2N6 | [MDL Number]
MFCD07779463 | [MOL File]
7139-02-8.mol | [Molecular Weight]
367.282 |
| Chemical Properties | Back Directory | [Melting point ]
249-251℃ | [Boiling point ]
504.1±50.0 °C(Predicted) | [density ]
1.386±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly) | [form ]
Solid | [pka]
2.00±0.30(Predicted) | [color ]
Pale Yellow to Light Yellow | [InChI]
InChI=1S/C16H20Cl2N6/c17-15-20-12-11(13(21-15)23-7-3-1-4-8-23)19-16(18)22-14(12)24-9-5-2-6-10-24/h1-10H2 | [InChIKey]
PCVJQTVUJJJSRQ-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(N2CCCCC2)=C2N=C(Cl)N=C(N3CCCCC3)C2=N1 | [LogP]
2 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
An antitumor nucleoside pyrimido pyrimidine. | [Synthesis]
General procedure for the synthesis of 2,6-dichloro-4,8-dipiperidinosubstituted pyrimido[5,4-d]pyrimidines from hexahydropyridine and perchloropyrimido[5,4-d]pyrimidines: perchloropyrimido[5,4-d]pyrimidines (13.1 g, 48.9 mmol), piperidines, CuI (0.28 g, 1.5 mmol) and Cs2CO3 (16.0 g, 48.9 mmol) were added to a 250mL two-necked flask. 100 mL of nitrobenzene was added as reaction solvent and the reaction was carried out at 180°C for 16 h under nitrogen protection. After completion of the reaction, the nitrobenzene solvent was removed by distillation under reduced pressure. Purification by column chromatography using a solvent mixture of petroleum ether (PE) and dichloromethane (DCM) (6:1, v/v) gave 17.0 g of solid product in 95.0% yield and 99% selectivity. | [References]
[1] Patent: CN106946887, 2017, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4905 - 4922
[3] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3906 - 3920
[5] Patent: CN108069972, 2018, A. Location in patent: Paragraph 0005; 0017 |
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