| Identification | Back Directory | [Name]
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea | [CAS]
724453-98-9 | [Synonyms]
Diflapolin
Urea, N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)-
1-(4-(Benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea ISO 9001：2015 REACH
diseases,Inhibitor,permeability,neutrophil,Epoxide Hydrolase,Diflapolin,vascular,FLAP,infiltration,5-LO activating protein,inflammation,cysteinyl-LTs,inhibit | [Molecular Formula]
C22H17Cl2N3O2S | [MDL Number]
MFCD04092440 | [MOL File]
724453-98-9.mol | [Molecular Weight]
458.36 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:42.0(Max Conc. mg/mL);91.63(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Synthesis and structure-activity relationships of Diflapolin analogs as dual sol. Epoxide Hydrolase /5-Lipoxygenase-activating protein inhibitors.FLAP inhibitor. | [in vivo]
Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments[1]. | Animal Model: | Male CD-1 mice (zymosan-induced peritonitis mouse model)[1] | | Dosage: | 1, 3 and 10?mg/kg | | Administration: | I.p.; 30?min before zymosan injection | | Result: | Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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