| Identification | Back Directory | [Name]
Rhynchophylline | [CAS]
76-66-4 | [Synonyms]
NSC-21731
mitrinermin
MITRINERMINE
UNCARINE D(P)
rhyncophylline
rhynchophyllin
RHYNCHOPHYLLINE
RHYNCHOLPHYLLINE
16e,20-alpha)-(7-bet
(7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
Methyl (E)-2-[(6'R,7'S)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)- | [Molecular Formula]
C22H28N2O4 | [MDL Number]
MFCD00221748 | [MOL File]
76-66-4.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [Melting point ]
216°; mp 197-199° (Ban et al., loc. cit.) | [alpha ]
D13 -14.7° (c = 2.5 in chloroform) | [Boiling point ]
560.8±50.0 °C(Predicted) | [density ]
1.23 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.4(at 25℃) | [color ]
White to Off-White | [λmax]
247nm(lit.) | [Merck ]
14,8197 | [Stability:]
Hygroscopic | [InChIKey]
DAXYUDFNWXHGBE-QCJVZUPCSA-N | [LogP]
3.311 (est) | [CAS DataBase Reference]
76-66-4 |
| Hazard Information | Back Directory | [Chemical Properties]
Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, almost insoluble in petroleum ether. Derived from the hooked branches of Uncaria rhynchopylla (Miq.) Jacks. | [Uses]
Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor. | [Definition]
ChEBI: A natural product found in Uncaria macrophylla. | [in vivo]
Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage[2].
Rhynchophylline (100 μM, 2 μL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice[6].
| Animal Model: | Aβ1-42(1.6 μM, 2 μL) treated rats[5] | | Dosage: | 100 μM, 2 μL | | Administration: | injected bilaterally in the hippocamp | | Result: | Rescued the soluble Aβ1-42-induced spatial learning and memory deficits.
Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs.
|
| [storage]
Store at 2-8°C, protect from light | [References]
See Rhyncophylline |
|
|