| Identification | More | [Name]
3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE | [CAS]
76041-71-9 | [Synonyms]
3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE
3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINOL
3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-OL
BUTTPARK 45\01-15
3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine 98%
3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine98% | [Molecular Formula]
C6H3ClF3NO | [MDL Number]
MFCD00153095 | [Molecular Weight]
197.54 | [MOL File]
76041-71-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
159-161 °C (lit.) | [Boiling point ]
234.6±40.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Solid | [pka]
8.06±0.10(Predicted) | [Appearance]
White to off-white Solid | [Detection Methods]
HPLC | [InChI]
1S/C6H3ClF3NO/c7-4-1-3(6(8,9)10)2-11-5(4)12/h1-2H,(H,11,12) | [InChIKey]
AJPOOWWMZOPUCG-UHFFFAOYSA-N | [SMILES]
Oc1ncc(cc1Cl)C(F)(F)F | [CAS DataBase Reference]
76041-71-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow solid | [Synthesis]
General procedure for the synthesis of 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine from 2-hydroxy-5-(trifluoromethyl)pyridine: 2-hydroxy-5-(trifluoromethyl)pyridine (15.3 g, 0.094 mol) and N-chlorosuccinimide (14.4 g, 0.108 mol) were dissolved in 50 mL of anhydrous N,N-dimethylformamide (DMF) and nitromethane in a in a mixed solvent. The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, the reaction solution was slowly poured into 250 mL of water and a light yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 17.1 g (0.087 mol) of 3-chloro-5-trifluoromethyl-2-hydroxypyridine in 92% yield. | [References]
[1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0025 |
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