| Identification | Back Directory | [Name]
1-Piperidineacetamide, N-[6-[(3,4-dihydro-2-phenyl-2H-1-benzopyran-6-yl)oxy]-3-pyridinyl]-4-hydroxy- | [CAS]
763926-98-3 | [Synonyms]
1-Piperidineacetamide, N-[6-[(3,4-dihydro-2-phenyl-2H-1-benzopyran-6-yl)oxy]-3-pyridinyl]-4-hydroxy- | [Molecular Formula]
C27H29N3O4 | [MOL File]
763926-98-3.mol | [Molecular Weight]
459.54 |
| Chemical Properties | Back Directory | [Boiling point ]
704.2±60.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (544.02 mM) | [form ]
Solid | [pka]
13.14±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ORM-10962 can be synthesized from 6-Hydroxyflavanone (H942412), a flavonoid/universal plant pigment. | [in vivo]
ORM-10962 (0.3 mg/kg, IV, once) pre-treatment significantly delays the development and recurrence of ventricular extrasystoles (by about 50%) or ventricular tachycardia (by about 30%) in anesthetized guinea pigs[1]. | Animal Model: | Male guinea-pigs (250-300 g)[1] | | Dosage: | 0.3 mg/kg | | Administration: | IV, 10 min before starting ouabain infusion | | Result: | Significantly delayed the development of ventricular extrasystoles (from 24±1.7 min in controls to 36.6±2.7 min in the presence of the drug) or ventricular tachycardia (from 31.8±1.8 min in controls to 40.8±2.1 min in the presence of the drug). |
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