| Identification | Back Directory | [Name]
LEVOCABASTINE HYDROCHLORIDE | [CAS]
79547-78-7 | [Synonyms]
547
R50547
LIVOSTIN
LEVOPHTA
LEVOSTIN
Unii-124xma6yei
(3S,4R)-Cabastine
LEVOCABASTINE HCL
LIVOSTIN USP/EP/BP
(3S,4R)-Cabastine HCl
LEVOCABASTINE HYDROCHLORIDE
(3S,4R)-Cabastine Hydrochloride
Levocabastine hydrochloride CRS
Levocabastine Hydrochloride (50 mg)
Levocabastine Hydrochloride (1359856)
Levocabastine for system suitability 2
Levocabastine for system suitability 1 CRS
Levocabastine for system suitability 2 CRS
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
[3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid
(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylicacid,hydrochloride
1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP
(3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]- 3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
4-Piperidinecarboxylicacid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,hydrochloride (1:1), (3S,4R)-
4-Piperidinecarboxylic acid, 1-(cis-4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)-
[3S-[1(CIS),3ALPHA,4BETA]]-1-[4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXYL]-3-METHYL-4-PHENYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI)
4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]-
Levophta, Levostin, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid | [EINECS(EC#)]
209-062-5 | [Molecular Formula]
C26H30ClFN2O2 | [MDL Number]
MFCD07787408 | [MOL File]
79547-78-7.mol | [Molecular Weight]
456.98 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~10 mg/mL, soluble
| [form ]
solid
| [color ]
white
| [Major Application]
pharmaceutical (small molecule) | [InChIKey]
OICFWWJHIMKBCD-VALQNVSPSA-N | [SMILES]
Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4 |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white powder. | [Uses]
A histamine H1 receptor antagonist | [Brand name]
Livostin (Novartis). | [Description]
Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor
antagonist without anticholinergic or antiserotonergic side effects. It is reported to
have both a fast onset and long duration of action. Indications are the treatment of
allergic conjunctivitis and allergic rhinitis. | [Originator]
Janssen (Johnson & Johnson) (U.S.A.) | [Definition]
ChEBI: Livostin (TN) is a member of piperidines. | [Manufacturing Process]
4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by
addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base
catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is
synthesized an intermediate that after decarboethoxylation gives 1-(4-
fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5-
phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4-
oxycyclohexanecarbonitrile under reductive hydrogenation conditions
(palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4-
piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-
4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed
by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-
fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is
transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)
cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))-
(Levocabastine hydrochloride) | [Therapeutic Function]
Antihistaminic |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [HS Code ]
2933399090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|