| Identification | More | [Name]
Levocetirizine dihydrochloride | [CAS]
130018-87-0 | [Synonyms]
[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
LEVOCETIRIZINE 2HCL
LEVOCETIRIZINE DIHCL
LEVOCETIRIZINE DIHYDROCHLORIDE
LEVOCETIRIZINE HCL
LEVOCETRIZINE DIHYDROCHLORIDE
LevocetrizineHCl
LEVOCITIRIZINE DIHYDROCHLORIDE
(R)-2-[2-[4-[(4-Chlorophenyl) phenylmethyl] piperazin-1-yl]ethoxy]acetic acid dihydrochloride
(2-(4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl)ethoxy)acetic acid dihydrochloride | [EINECS(EC#)]
641-093-3 | [Molecular Formula]
C21H27Cl3N2O3 | [MDL Number]
MFCD07366507 | [Molecular Weight]
461.81 | [MOL File]
130018-87-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
215-220°C | [alpha ]
D25 -12.79° (c = 1 in water) | [storage temp. ]
room temp | [solubility ]
H2O: ≥23mg/mL | [form ]
powder | [color ]
White to Almost white | [Water Solubility ]
H2O: ≥23mg/mL | [Merck ]
14,2022 | [Stability:]
Hygroscopic | [InChI]
InChI=1/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/s3 | [InChIKey]
PGLIUCLTXOYQMV-MGIYCFTINA-N | [SMILES]
C(O)(=O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C2=CC=CC=C2)CC1.[H]Cl.[H]Cl |&1:11,r| | [CAS DataBase Reference]
130018-87-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [RTECS ]
AG0990000 | [HS Code ]
29335990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1 |
| Hazard Information | Back Directory | [Uses]
Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis. | [Uses]
Anti Histaminic | [General Description]
Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine . | [Biochem/physiol Actions]
Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor. |
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