| Identification | Back Directory | [Name]
Levomepromazine hydrochloride | [CAS]
1236-99-3 | [Synonyms]
Einecs 214-978-3
LevomepromazineHCl
7044 Rp hydrochloride
Levomepromazinium chloride
Levopromazine hydrochloride
Levomepromazine hydrochloride
Levomepromazine D6 hydrochloride
Levomepromazine hydrochloride CRS
Levomepromazine hydrochloride [usan:jan]
TIANFU-CHEM CAS NO.1236-99-3 Levomepromazine hydrochloride
3-(2-methoxy-10-phenothiazinyl)-N,N,2-trimethyl-1-propanamine
10-(3-Dimethylamino-2-methylpropyl)-2-methoxyphenothiazine hydrochloride
(R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropylamine hydrochloride
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (R)-
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, monohydrochloride, (bR)- (9CI)
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, monohydrochloride, (R)- (9ci) | [EINECS(EC#)]
214-978-3 | [Molecular Formula]
C19H24N2OS.ClH | [MOL File]
1236-99-3.mol | [Molecular Weight]
364.93 |
| Hazard Information | Back Directory | [Originator]
Levoprome ,Lederle,US,1966 | [Uses]
Analgesic (central nervous system depressant). | [Definition]
ChEBI: Levomepromazine hydrochloride is a member of phenothiazines. | [Manufacturing Process]
95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C. | [Brand name]
Nozinan (Aventis). | [Therapeutic Function]
Analgesic |
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