| Identification | More | [Name]
HOMATROPINE METHYL BROMIDE | [CAS]
80-49-9 | [Synonyms]
8-METHYLHOMATROPINIUM BROMIDE
ARKITROPIN
DL-HOMATROPINE METHYL BROMIDE
ESOPIN
HOMATROPINE METHYL BROMIDE
HOMOLONE
N-METHYLHOMATROPINIUM BROMIDE
TROPINIUM METHOBROMIDE MANDELATE
3-((hydroxyphenylacetyl)oxy)-8,8-dimethyl-8-azoniabicyclo(3.2.1)octanbro
3-[(hydroxyphenylacetyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octanbromi
3-alpha-hydroxy-8-methyl-1-alpha-h,5-alpha-h-tropaniumbromidemandelate
8-methyl-homatropiniubromide
camatropine
dl-methylbromide
endo-mid
homapin
homatromide
malcotran
mesopin
methylhomatropine | [EINECS(EC#)]
201-284-0 | [Molecular Formula]
C17H24BrNO3 | [MDL Number]
MFCD00050292 | [Molecular Weight]
370.28 | [MOL File]
80-49-9.mol |
| Safety Data | Back Directory | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1544 | [WGK Germany ]
3 | [RTECS ]
MS9000000 | [TSCA ]
TSCA listed | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29399990 | [Toxicity]
LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder or colourless crystals | [Uses]
anticholinergic (opthalmic) | [Uses]
Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile. | [Brand name]
Equipin (Mission); Homapin (Mission). | [General Description]
Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine). | [Clinical Use]
Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms. |
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