| Identification | Back Directory | [Name]
LP 44 | [CAS]
824958-12-5 | [Synonyms]
LP 44
LP44 (hydrochloride)
4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamidehydrochlo
4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride
6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide:hydrochloride | [Molecular Formula]
C27H37N3OS.ClH | [MDL Number]
MFCD09971090 | [MOL File]
824958-12-5.mol | [Molecular Weight]
488.136 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
White to off-white | [InChIKey]
DWGKCWWWKHCVDH-UHFFFAOYSA-N | [SMILES]
Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2 |
| Hazard Information | Back Directory | [Uses]
LP 44 Hydrochloride is used in the preparation of (tetrahydronaphthalenyl)arylpiperazinealkylamides which an agonist of the serotonin 5-HT7 receptor. | [Biological Activity]
High affinity 5-HT 7 receptor agonist (K i = 0.22 nM) that displays selectivity over 5-HT 1A and 5-HT 2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC 50 = 2.56 μ M). | [in vivo]
LP44 (hydrochloride) (5.1, 10.3, 20.5, 41.0 nmol; i.c.v.) produces dose-dependent hypothermic effect in CBA mice[1]. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|