| Identification | More | [Name]
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole | [CAS]
84163-77-9 | [Synonyms]
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HCL
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE
6-FLUORO-3-(4-PIPERIDYL)-1,2-BENZOISOXAZOLE HCL
6-FLUORO-3-PIPERID-4-YL-1,2-BENZISOXAZOLE HCL
6-FLUORO-3-PIPERID-4-YL-1,2-BENZISOXAZOLE HYDROCHLORIDE
6-Fluoro-3-(4-Piperidinyl)C1,2-Benzisoxazole
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE(FOR RISPERIDONE&ILOPERIDONE)
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZO[D]ISOXAZOLE
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE 98+% | [EINECS(EC#)]
617-540-3 | [Molecular Formula]
C12H13FN2O | [MDL Number]
MFCD06658529 | [Molecular Weight]
220.24 | [MOL File]
84163-77-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Powder | [Melting point ]
59-62°C | [Boiling point ]
359.0±42.0 °C(Predicted) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.74±0.10(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChI]
1S/C12H13FN2O/c13-9-1-2-10-11(7-9)16-15-12(10)8-3-5-14-6-4-8/h1-2,7-8,14H,3-6H2 | [InChIKey]
MRMGJMGHPJZSAE-UHFFFAOYSA-N | [SMILES]
Fc1ccc2c(noc2c1)C3CCNCC3 | [CAS DataBase Reference]
84163-77-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-36/37/38 | [Safety Statements ]
45-26 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29349990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Powder | [Uses]
An Intermediate in the synthesis of risperidone and iloperidone. | [Synthesis]
The general procedure for the synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole from (2,4-difluorophenyl)-(4-piperidinyl)methanone oxime hydrochloride (5.52 g, 20 mmol) is as follows: The raw material was added to 25 mL of 50% potassium hydroxide solution and the reaction was carried out at reflux for 4 hours. After completion of the reaction, it was cooled to room temperature and extracted with toluene (25 mL × 2). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure. The crude product was recrystallized in ether to give 3.3 g of the target product in 75% yield. | [References]
[1] Patent: EP2322520, 2011, A1. Location in patent: Page/Page column 16
[2] Patent: JP5714152, 2015, B2. Location in patent: Paragraph 0089 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Gow Chemical Corp. Limited
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+86 (512) 8883-1178 |
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www.chemicalbook.com/ShowSupplierProductsList15648/0_EN.htm |
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