| Identification | More | [Name]
Felodipine | [CAS]
86189-69-7 | [Synonyms]
4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID ETHYL METHYL ESTER
4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL ESTER
4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL ESTER
ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
FELODAY
FELODIPINE
FLODIL
PLENDIL
Felodipine | [Molecular Formula]
C18H19Cl2NO4 | [MDL Number]
MFCD00868316 | [Molecular Weight]
384.25 | [MOL File]
86189-69-7.mol |
| Chemical Properties | Back Directory | [solubility ]
DMSO: 28 mg/mL
| [form ]
solid
| [color ]
light yellow
| [BCS Class]
2 | [InChI]
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 | [InChIKey]
RZTAMFZIAATZDJ-UHFFFAOYSA-N | [SMILES]
O=C(OC)C1C(C2=C(Cl)C(Cl)=CC=C2)C(C(=O)OCC)=C(C)NC=1C | [CAS DataBase Reference]
86189-69-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Vasodilator. | [Brand name]
Plendil (AstraZeneca). | [Clinical Use]
Calcium-channel blocker:HypertensionAngina | [Drug interactions]
Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased
aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials metabolism possibly inhibited by
clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antiepileptics: effect reduced by carbamazepine,
barbiturates, phenytoin and primidone.
Antifungals: metabolism inhibited by itraconazole
and ketoconazole; negative inotropic effect possibly
increased with itraconazole.
Antihypertensives: enhanced hypotensive effect,
increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration possibly increased by
ritonavir; use with caution with telaprevir.
Grapefruit juice: concentration increased - avoid
concomitant use.
Tacrolimus: possibly increased tacrolimus
concentration | [Metabolism]
Felodipine is metabolised in the liver and all identified
metabolites are devoid of vasodilating properties.
Approximately 70% of a given dose is excreted as
metabolites in the urine and about 10% with the faeces.
Less than 0.5% of the dose is excreted unchanged in the
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