| Identification | Back Directory | [Name]
FMoc-NH-8(ethylene glycol)-acetic acid | [CAS]
868594-52-9 | [Synonyms]
Fmoc-NH-PEG8-CH2CO2H
FMoc-NH-PEG8-CH2COOH
Fmoc-PEG8-acetic acid
Fmoc-NH-8(ethylene glycol)-actic acid
FMoc-NH-8(ethylene glycol)-acetic acid
FMoc-NH-8(ethylene glycol)-acetic acid ISO 9001：2015 REACH
26-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15,18,21,24-octaoxahexacosanoic acid
26-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18,21,24-octaoxahexaeicosanoic acid
5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester | [Molecular Formula]
C33H47NO12 | [MDL Number]
MFCD27635163 | [MOL File]
868594-52-9.mol | [Molecular Weight]
649.726 |
| Chemical Properties | Back Directory | [Boiling point ]
773.7±60.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 100 mg/mL (153.91 mM; Need ultrasonic) | [form ]
Oil | [pka]
3.39±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
Fmoc-NH-PEG8-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17. |
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