| Identification | Back Directory | [Name]
HS-PEG4-tBu | [CAS]
564476-33-1 | [Synonyms]
HS-PEG4-tBu
HS-PEG4-COOtBu
Thiol-PEG4-Boc
Thiol-dPEG4-t-boc
HS-PEG4-CH2CH2COOtBu
SH-PEG4-CH2CH2COOtBu
HS-PEG?-CH?CH?COOtBu
Thio-PEG4-t-butyl ester
Thiol-PEG4-t-butyl ester
t-Butyl 3-mercapto(peg4)propionate
1-Sulfanyl-3,6,9,12-tetraoxapentadecan-15-oic acid
HS-PEG4-CH2CH2COOtBu
15-Mercapto-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester
15-Mercapto-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester
4,7,10,13-Tetraoxapentadecanoic acid, 15-mercapto-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H30O6S | [MDL Number]
MFCD11041133 | [MOL File]
564476-33-1.mol | [Molecular Weight]
338.46 |
| Chemical Properties | Back Directory | [Boiling point ]
414.6±40.0 °C(Predicted) | [density ]
1.060±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Liquid | [pka]
9?+-.0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Thiol-PEG4-t-butyl ester is a PEG linker containing a thiol group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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