| Identification | More | [Name]
5-Bromoisatin | [CAS]
87-48-9 | [Synonyms]
5-BROMO-1H-INDOLE-2,3-DIONE
5-BROMOINDOLE-2,3-DIONE
5-BROMOINDOLE-2,3-DIONE HEMIHYDRATE
5-BROMOINDOLINE-2,3-DIONE
5-BROMOISATIN
5-BROMOISATIN HEMIHYDRATE
AKOS B028934
AKOS BBS-00000997
BUTTPARK 50\07-94
1H-Indole-2,3-dione,5-bromo-
5-bromisatin
5-bromo-1h-indole-3-dione
5-bromo-indole-3-dione
5-bromo-isati
5-BROMOISATIN, TECH., 90%
BromoIsatin
5-Bromoisatin,tech.90%
5-BROMOISATIN, 98+%
5-BROMO-3-CHLORO-2-METHYLPYRIDINE
5-Bromoisatin, 90+% | [EINECS(EC#)]
201-747-7 | [Molecular Formula]
C8H4BrNO2 | [MDL Number]
MFCD00005719 | [Molecular Weight]
226.03 | [MOL File]
87-48-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Orange crystalline powder | [Melting point ]
247-252 °C (lit.) | [density ]
1.7498 (rough estimate) | [refractive index ]
1.6120 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in N,N dimethylformamide. | [form ]
Crystalline Powder | [pka]
8.74±0.20(Predicted) | [color ]
Orange | [BRN ]
383760 | [InChI]
InChI=1S/C8H4BrNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12) | [InChIKey]
MBVCESWADCIXJN-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(Br)C=C2)C(=O)C1=O | [CAS DataBase Reference]
87-48-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
2
| [RTECS ]
NL7875000
| [Hazard Note ]
Irritant | [HS Code ]
29337900 |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
5-Bromoisatoic anhydride-->6-Bromo-3-hydroxyquinoline-->5-Nitroisatoic anhydride-->6-Bromoisatinic anhydride-->5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl) indolin-2-one-->5-Bromo-1H-indazole-3-carbaldehyde-->6-Bromo-2-(4-bromo-phenyl)-quinoline-4-carboxylic acid-->7-Bromo-1,2,3,4-tetrahydro-acridine-9-carboxylic acid-->4-Quinolinecarboxylic acid, 6-bromo-2-(2-fluoro-5-methylphenyl)--->4-Quinolinecarboxylic acid, 6-bromo-2-(4-fluoro-2-methylphenyl)--->Hydrazinecarbothioamide, 2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)--->5-Bromo-1H-indazole-3-carboxylic acid-->5-bromo-1-ethyl-1H-indole-2,3-dione |
| Hazard Information | Back Directory | [Chemical Properties]
Orange crystalline powder | [Uses]
Indole derivative | [Definition]
ChEBI: 5-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent. | [Synthesis Reference(s)]
Tetrahedron Letters, 25, p. 3099, 1984 DOI: 10.1016/0040-4039(84)80017-9 | [General Description]
5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice. | [Purification Methods]
5-Bromoisatin forms red prisms or needles from EtOH. The N-acetate crystallises as yellow prisms from *C6H6, m 170-172o, and the N-methyl derivative forms orange-red needles from MeOH, m 172-173o. [Heller Chem Ber 53 1545 1920, Buu-Hoi Recl Trav Chim, Pays-Bas 73 197 1954, Baker etal. Tetrahedron Lett 215 1978, Beilstein 21 H 453, 21 III/IV 5009.] |
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