| Identification | Back Directory | [Name]
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one | [CAS]
870281-86-0 | [Synonyms]
Idelalisib INT
IdelalisibIntermediates 1
CAL-101 (N-1) Intermediate
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one | [Molecular Formula]
C17H16FN3O | [MDL Number]
MFCD22124614 | [MOL File]
870281-86-0.mol | [Molecular Weight]
297.327 |
| Chemical Properties | Back Directory | [Boiling point ]
455.3±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly) | [form ]
Solid | [pka]
8.23±0.29(Predicted) | [color ]
Off-White |
| Hazard Information | Back Directory | [Uses]
2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone is used as reagent/reactant in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step. |
|
|