| Identification | Back Directory | [Name]
Ganoderone A | [CAS]
873061-79-1 | [Synonyms]
Ganoderone A
(24E)-26-Hydroxy-lanosta-8,24-diene-3,7-dione
5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione
Lanosta-8,24-diene-3,7-dione, 26-hydroxy-, (24E)- | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD21364026 | [MOL File]
873061-79-1.mol | [Molecular Weight]
454.68 |
| Chemical Properties | Back Directory | [Boiling point ]
568.0±50.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
14.85±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ganoderone A is a triterpene compound that can be isolated from the fruiting body of Ganoderma pfeifferi and Ganoderma calidophilum. Ganoderone A has antiviral activity against HSV with IC50 value of 0.3 μg/mL. Ganoderone A has potential applications in viral infections and tumors[1][2][3]. | [Definition]
ChEBI: Ganoderone A is a tetracyclic triterpenoid that is 5alpha-lanosta-8,24-diene substituted by a hydroxy group at position 26 and oxo groups at positions 3 and 7. Isolated from the fruiting bodies of Ganoderma pfeifferi, it exhibits against herpes simplex virus. It has a role as a metabolite and an anti-HSV-1 agent. It is a tetracyclic triterpenoid, a diketone and a primary alcohol. It derives from a hydride of a lanostane. | [target]
HSV | Integrase | [IC 50]
HSV: 0.3 μg/mL (IC50) | [References]
[1] Niedermeyer TH, et al. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod. 2005 Dec;68(12):1728-31. DOI:10.1021/np0501886
[2] Huang S Z, et al. Anti-allergic prenylated hydroquinones and alkaloids from the fruiting body of Ganoderma calidophilum[J]. RSC advances, 2016, 6(25): 21139-21147.
[3] Huang SZ, et al. Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. Phytochemistry. 2017 Nov;143:104-110. DOI:10.1016/j.phytochem.2017.07.015 |
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