| Identification | Back Directory | [Name]
DUP-697 | [CAS]
88149-94-4 | [Synonyms]
BFMeT
DUP-697
DuP-697 Assay Reagent
5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE
Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]- | [Molecular Formula]
C17H12BrFO2S2 | [MDL Number]
MFCD02684527 | [MOL File]
88149-94-4.mol | [Molecular Weight]
411.31 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml | [form ]
White to off-white solid. | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin. | [Uses]
DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID. | [Definition]
ChEBI: DuP 697 is a member of thiophenes. | [Biological Activity]
Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active. | [storage]
Store at +4°C | [References]
[1] STACIA KARGMAN. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells[J]. Biochemical pharmacology, 1996, 52 7: Pages 1113-1125. DOI: 10.1016/0006-2952(96)00462-5
[2] K SEIBERT. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.[J]. British Journal of Pharmacology, 1996, 117 6: 1016-1020. DOI: 10.1111/j.1476-5381.1996.tb16691.x
[3] MOTI ROSENSTOCK Gilad R Abraham Danon. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1999, 1440 1: Pages 127-137. DOI: 10.1016/s1388-1981(99)00105-5 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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