| Identification | Back Directory | [Name]
m-PEG4-t-butyl ester | [CAS]
883554-11-8 | [Synonyms]
m-PEG4-Boc
mPEG4-CH2CH2COOtBu
mPEG3-CH2CH2COOtBu
m-PEG4-t-butyl ester
tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate
4,7,10,13-Tetraoxatetradecanoic acid, 1,1-dimethylethyl ester
tert-Butyl 3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}propionate/m-PEG4-t-butyl ester | [Molecular Formula]
C14H28O6 | [MDL Number]
MFCD26388566 | [MOL File]
883554-11-8.mol | [Molecular Weight]
292.37 |
| Hazard Information | Back Directory | [Description]
m-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. | [IC 50]
PEGs; Cleavable Linker | [References]
[1] Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.
[2] Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1. |
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Nextpeptide Inc
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http://www.nextpeptide.com/ |
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