| Identification | Back Directory | [Name]
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid | [CAS]
16142-03-3 | [Synonyms]
mPEG5-CH2COOH
MPEG5-OCH2COOH
m-PEG6-CH4COOH
mPEG5-acetic acid
3,6,9,12,15,18-Hexaoxanonadecanoic acid
[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid | [Molecular Formula]
C13H26O8 | [MDL Number]
MFCD30536160 | [MOL File]
16142-03-3.mol | [Molecular Weight]
310.34 |
| Chemical Properties | Back Directory | [Boiling point ]
418.6±40.0 °C(Predicted) | [density ]
1.124±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.39±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C13H26O8/c1-16-2-3-17-4-5-18-6-7-19-8-9-20-10-11-21-12-13(14)15/h2-12H2,1H3,(H,14,15) | [InChIKey]
WJNNCBSSWKTIHI-UHFFFAOYSA-N | [SMILES]
C(O)(=O)COCCOCCOCCOCCOCCOC |
| Hazard Information | Back Directory | [Description]
m-PEG6-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Biological Activity]
m-PEG5-CH2COOH is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Non-cleavable < span> | PEGs | |
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