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883976-12-3

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883976-12-3 Structure

883976-12-3 Structure
IdentificationBack Directory
[Name]

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
[CAS]

883976-12-3
[Synonyms]

M8-B
M8-B hydrochloride
M8-B hydrochloride >=98% (HPLC)
N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride
N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride
[Molecular Formula]

C22H25ClN2O3S
[MDL Number]

MFCD27978374
[MOL File]

883976-12-3.mol
[Molecular Weight]

432.964
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble2mg/mL, clear (warmed)
[form ]

powder
[color ]

white to beige
[Water Solubility ]

H2O: 2mg/mL, clear (warmed)
[InChI]

1S/C22H24N2O3S.ClH/c1-26-20-14-18(9-10-19(20)27-16-17-6-3-2-4-7-17)15-24(12-11-23)22(25)21-8-5-13-28-21;/h2-10,13-14H,11-12,15-16,23H2,1H3;1H
[InChIKey]

FMQJBHACRTZLME-UHFFFAOYSA-N
[SMILES]

[s]1c(ccc1)C(=O)N(CCN)Cc2cc(c(cc2)OCc3ccccc3)OC.Cl
Safety DataBack Directory
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Description]

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.
[Uses]

M8 B Hydrochloride is a channel blocker of cold receptor TRPM8.
[in vivo]

M8-B (6 mg/kg; i.v. or i.p.) decreases deep body body temperature (Tb) in rats and mouse[1].

Animal Model:Trpm8+/+ rats and mice[1]
Dosage:6 mg/kg
Administration:I.v. or i.p.
Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
[IC 50]

TRPM8
[storage]

Store at +4°C
[References]

[1] M CAMILA ALMEIDA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.[J]. Journal of Neuroscience, 2012, 32 6: 2086-2099. DOI: 10.1523/jneurosci.5606-11.2012
Spectrum DetailBack Directory
[Spectrum Detail]

N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride(883976-12-3)1HNMR
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