| Identification | Back Directory | [Name]
Disodium clodronate tetrahydrate | [CAS]
88416-50-6 | [Synonyms]
BONEFOS
CLASTEON
CLASTOBAN
CLODRONATE DISODIUM SALT
Disodium clodronate tetrahydrate
Clodronate (sodium salt hydrate)
Clodronate disodiuM(tetrehydrate)
DisodiumClodronateTetrahydrate>
CLODRONATE, DISODIUM, TETRAHYDRATE
Clodronate disodium tetrahydrate CRS
clodronic acid disodium tetrahydrate
CLODRONATE, DISODIUM SALT, TETRAHYDRATE
CLODRONIC ACID, DISODIUM SALT, TETRAHYDRATE
(Dichlorormethylene)diphosphonic acid, disodium salt
Disodium Clodronate Tetrahydrate Duplicate of C586875
Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem
DICHLOROMETHYLENE-BISPHOSPHONATE, DISODIUM TETRAHYDRATE
Dichloromethylenediphosphonic acid disodium salt tetrahydrate
(Dichloromethylene)bisphosphonic acid disodium salt tetrahydrate
Disodium clodronate tetrahydrateQ: What is
Disodium clodronate tetrahydrate Q: What is the CAS Number of
Disodium clodronate tetrahydrate Q: What is the storage condition of
Disodium clodronate tetrahydrate Q: What are the applications of
Disodium clodronate tetrahydrate | [Molecular Formula]
CH10Cl2Na2O10P2 | [MDL Number]
MFCD02940846 | [MOL File]
88416-50-6.mol | [Molecular Weight]
360.92 |
| Chemical Properties | Back Directory | [storage temp. ]
+2C to +8C | [solubility ]
Soluble in Water (up to at least 10 mg/ml) | [form ]
White solid | [color ]
White | [Water Solubility ]
water: 1mg/mL | [Merck ]
14,2371 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. | [InChI]
1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2 | [InChIKey]
XWHPUCFOTRBMGS-UHFFFAOYSA-L | [SMILES]
[Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O |
| Hazard Information | Back Directory | [Description]
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.1,2 Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption.3 Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts.4 Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.5 | [Uses]
Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator. | [Definition]
ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions
nd bone pain associated with skeletal metastases. | [in vivo]
Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1].
| Animal Model: | C57BL/6 mice (22-30 g)[1] | | Dosage: | 10 mg/kg | | Administration: | Intravenous injection | | Result: | Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain. |
| [References]
1) Plosker and Goa (1994), Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease; Drugs 47 945
2) Lehenkari et al. (2002), Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite; Mol.Pharmacol. 61 1255 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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