ChemicalBook--->CAS DataBase List--->9004-57-3

9004-57-3

9004-57-3 Structure

9004-57-3 Structure
IdentificationBack Directory
[Name]

Ethyl cellulose
[CAS]

9004-57-3
[Synonyms]

ets
g50
g200
t100
ethocel
aquacoat
nixone/c
spt50cps
ethocele7
ethoceln7
ethocelstd
ethocelmed
ethoceln10
ethocel150
ethocel890
ethocele50
ampacete/c
ethoceln200
AQUACOATECD
ethoceln-200
'ETHOCEL'(R)
aquacoatecd30
celluloseethyl
EC)Ethyl cellu
ETHYL CELLULOSE
aquacoatecd30fmc
celluloseethylate
triethylcellulose
Ethylcellulose M9
ETHYLCELLULOSE,NF
EC/Ethyl cellulose
ETHYL CELLULOSE 10
ETHYL CELLULOSE 45
ETHYL CELLULOSE 50
MODIFIED CELLULOSE
Ethylcellulose(Ec)
ETHYLCELLULOSE,FCC
ETHYL CELLULOSE 100
g50(polysaccharide)
g50[polysaccharide]
ets(polysaccharide)
ets[polysaccharide]
Ethyl cellulose USP
g200(polysaccharide)
t100(polysaccharide)
CELLULOSE ETHYL ETHER
Ethylcellulose (1 g)
Ethyl cellulose ethoce
ETHYL CELLULOSE (22 N)
MODIFIED CELLULOSE, EC
Ethylcellulose 7 mPa s
ETHYL CELLULOSE, PH EUR
ETHYL CELLULOSE, 10 CPS
Ethylcellulose 45 mPa s
cellulose,triethylether
Ethyl cellulose,Ethocel
Ethyl cellulose, ethoxyl
et100(cellulosederivative)
ETHYL CELLULOSE, 5-15 MPA.S
ETHYL CELLULOSE, 9-11 MPA.S
ETHYL CELLULOSE, 45-55 MPA.S
Ethyl cellulose, 30-60 mPa.s
ETHYL CELLULOSE, 18-22 MPA.S
ETHYL CELLULOSE 3-5.5 MPA.S
ETHYL CELLULOSE, 90-110 MPA.S
Ethylcellulose coated vitamin
EthylCellulose[18-22mPa·
ETHYL CELLULOSE, 180-220 MPA.S
ETHYL CELLULOSE, 80-120 MPA.S*
ETHYL CELLULOSE, 140-180 MPA.S*
Ethyl cellulose,Ethylcellulosum
Ethyl Cellulose, Ethoxyl Content
EC Ethocel Cellulose ethyl ether
s,5%inToluene+Ethanol(80:20)at25°
EthylCellulose(Ec),EthoxylContent47.5%Min.
Ethyl cellulose, ethoxyl content 48%, 4 cps
Ethyl cellulose, ethoxyl content 48%, 7 cps
Ethyl cellulose, ethoxyl content 48%, 22 cps
Ethyl cellulose, ethoxyl content 48%, 10 cps
Ethyl cellulose, ethoxyl content 48%, 100 cps
Ethyl cellulose, ethoxyl content 49%, 100 cps
Ethyl cellulose, ethoxyl content 50%, 100 cps
Ethyl cellulose, ethoxyl content 46%, 100 cps
Ethyl cellulose, ethoxyl, content 48%, 300 cps
Ethyl cellulose, ethoxyl content 48%, 22 cps 500GR
ETHYL CELLULOSE, ETHOXYL CONTENT 48%, VI SCOSITY 46 CPS
Ethyl Cellulose [9-11mPa.s, 5% in Toluene + Ethanol (80:20) at 25°C]
Ethyl Cellulose [18-22mPa.s, 5% in Toluene + Ethanol (80:20) at 25°C]
Ethyl Cellulose [45-55mPa.s, 5% in Toluene + Ethanol (80:20) at 25°C]
Ethyl Cellulose [90-110mPa.s, 5% in Toluene + Ethanol (80:20) at 25°C]
Ethyl Cellulose [9-11mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C]
Ethyl Cellulose [45-55mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C]
Ethyl Cellulose [18-22mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C]
Ethyl Cellulose [90-110mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C]
Ethyl cellulose, 5% solution in toluene/ethanol (4/1), ethoxyl content 48%, 10 cps
2-[butyl({4-[(E)-2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]-3-Methylphenyl})aMino]ethyl acetate
Ethyl cellulose viscosity 4 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Ethyl cellulose viscosity 22 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Ethyl cellulose viscosity 46 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Ethyl cellulose viscosity 10 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Ethyl cellulose viscosity 100 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
Ethyl cellulose viscosity 300 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl
[EINECS(EC#)]

232-674-9
[Molecular Formula]

N/A
[MDL Number]

MFCD00131037
[MOL File]

9004-57-3.mol
[Molecular Weight]

448.474
Chemical PropertiesBack Directory
[Appearance]

white to slightly yellowish powder
[Melting point ]

240-255 °C
[density ]

1.14 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.47(lit.)
[storage temp. ]

room temp
[solubility ]

esters, aromatic hydrocarbons, alcohols and ketones: soluble
[form ]

powder
[color ]

White to slightly yellow
[Specific Gravity]

1.14
[Water Solubility ]

insoluble
[Merck ]

14,3781
[Dielectric constant]

2.8(Ambient)
[Uses]

Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit.
[EPA Substance Registry System]

Cellulose, ethyl ether(9004-57-3)
Hazard InformationBack Directory
[Chemical Properties]

white to slightly yellowish powder
[Uses]

Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates.
[Uses]

In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder).
[Definition]

ChEBI: Ethyl cellulose is a glycoside.
[Preparation]

Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl.
Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures.
[Production Methods]

Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical:
RONa + C2H5Cl→ROC2H5+NaCl
The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three.
[Brand name]

Aquacoat ECD (FMC);Ethocel (Dow Chemical).
[Pharmaceutical Applications]

Ethylcellulose is widely used in oral and topical pharmaceutical formulations.
The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former.
Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression.
High-viscosity grades of ethylcellulose are used in drug microencapsulation.
Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area.
In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution.
Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances.
In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions.
Ethylcellulose is additionally used in cosmetics and food products.
[Safety]

Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys.
Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material.
As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg
[storage]

Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters.
Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range.
Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents.
[Incompatibilities]

Incompatible with paraffin wax and microcrystalline wax.
[Regulatory Status]

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

1
[RTECS ]

FJ5950500
[F ]

3
[Autoignition Temperature]

698 °F
[TSCA ]

Yes
[HS Code ]

39129000
[Safety Profile]

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes
[Hazardous Substances Data]

9004-57-3(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

CHLOROETHANE-->Dehydrolyzing agent-->Microcrystalline cellulose
[Preparation Products]

Carbendazim-->PENTYL ETHER-->scavenger of fabric maculae
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Ethyl cellulose(9004-57-3).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Ethyl cellulose(9004-57-3)IR1
Ethyl cellulose(9004-57-3)IR2
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